Oocyte-donation Pregnancies, Preeclampsia
Conditions
Brief summary
The investigators conduct a study to evaluate the underlying causes of preeclampsia in oocyte-donation pregnancies.
Detailed description
A detailed medical history, questionnaires as well as blood, urine and placental samples will be used to analyse several factors leading to the high risk of preeclampsia in oocyte-donation pregnancies.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* pregnancy
Exclusion criteria
* severe auto immune disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Preeclampsia in oocyte-donation pregnancies is caused by an altered composition of immune cells in placenta and blood. | 01.01.2020 - 01.12.2025 | T-Cell populations are altered in preeclampsia. HLA-mismatch of mother and donor oocyte lead to a host-versus-graft reaction. T-, B- and Natural killer cells are altered in placental tissue of oocyte-donation pregnancies. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Preeclampsia in oocyte-donation pregnancies is caused by an activation of pro-inflammatory factors and endothelial dysfunction. | 01.01.2020 - 01.12.2025 | Altered Natural killer cells and B-cells in oocyte-donation pregnancies lead to endothelial dysfunction. Pro-inflammatory factors are higher in OD pregnancy and can be measured in placental tissue via single-cell sequencing. |
Countries
Germany
Contacts
Primary ContactFlorian Herse, DSc
Backup ContactJudith Altmann, MD
Outcome results
None listed