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Validation and Comparison of the Appendicitis Inflammatory Response Score and Adult Appendicitis Score

Prospective Clinical Trial on Validation and Comparison of the Diagnostic and Prognostic Value of Appendicitis Inflammatory Response Score and Adult Appendicitis Score

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04730752
Enrollment
174
Registered
2021-01-29
Start date
2021-03-01
Completion date
2021-05-25
Last updated
2021-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Appendicitis, Acute Appendicitis With Rupture

Brief summary

Acute appendicitis is one of the most frequent reasons of emergency laparotomy in adults. Symptoms of acute appendicitis overlap with other clinical conditions and might present as a challenge, especially in the early phases. Despite the advances and widespread use of imaging modalities, still negative laparotomies are performed with the initial diagnosis of acute appendicitis. Several scoring systems are developed by using various clinical and laboratory parameters in order to improve the diagnostic accuracy and prevent unnecessary laparotomies.

Detailed description

In the recent guideline of World Society of Emergency Surgeons (WSES) recommendations regarding the clinical scoring systems for acute appendicitis are remarkable. It is stated that clinical scoring systems, on their own, can be used to exclude acute appendicitis and decrease negative laparotomy rates. Currently Appendicitis Inflammatory Response Score (AIR) and Adult Appendicitis Score (AAS) are the best clinically performing scoring systems. As a result, based on strong evidence the use of these two systems are recommended. Both scoring systems are developed on the basis of clinical findings and laboratory parameters. The aim of this study is to validate both systems as well as to compare the efficiency of both systems on excluding negative laparotomies and on the determination of severity of acute appendicitis.

Interventions

DIAGNOSTIC_TESTAppendicitis Inflammatory Response

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

DIAGNOSTIC_TESTAdult Appendicitis Score

A scoring system used to diagnose acute appendicitis. It consists of clinical findings and laboratory parameters

Sponsors

Nigde Omer Halisdemir University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Presenting to ER with right lower quadrant pain * Patients between 18-65 years old.

Exclusion criteria

* Patients receiving immun-suppressive therapy * Patients with diagnosed malignancy * Presence of mental retardation * Patients with previous right hemicolectomy * Patients with previous appendectomy * Pregnant women

Design outcomes

Primary

MeasureTime frameDescription
Exclude acute appendicitis6 monthsThe ability of the scoring systems in detecting patients without acute appendicitis presenting with right lower quadrant pain to emergency service
Predicting the severity of acute appendicitis6 monthsThe ability of scoring systems in predicting the rate of perforation in patients with acute appendicitis

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026