Electrical Impedance Tomography, Epidural Block
Conditions
Brief summary
Define the effect of epidural block on HPV by EIT.
Detailed description
Epidural block may affect the physiological mechanism of hypoxic pulmonary vasoconstriction, which is still poorly understood. Electrical impedance tomography might be helpful in establishing the hypoxemia etiology at bedside via combining regional ventilation and perfusion information.
Interventions
DEVICEElectrical impedance tomography
A bolus of 10ml 10% NaCl was injected during a respiratory pause (≥10s) through the central venous catheter.The results of arterial blood gas analysis and the data of EIT were collected before the first prone session (time baseline), the end of prone positioning (time P).
Sponsors
Shanghai Zhongshan Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Age 18 - 80 years Existing central venous and arterial access Chest circumference 70 - 150 cm
Exclusion criteria
* Contraindication to central venous injection of 5 % sodium chloride (NaCl) Contraindications of PulmoVista 500: Patients with pacemakers, defibrillators or other electrically active implants Patients with damaged skin or impaired skin contact of the electrodes due to wound dressings Patients where the attachment of the patient belt could pose a risk to the patient, e.g. patients with spinal lesions or fractures Patients with uncontrolled body movements Extremely obese patients (BMI\>50) Patients during pregnancy Patients with massive lung edema Use during electricity-based therapies, such as electrosurgery or electrocautery Use in the presence of strong magnetic fields Use in conjunction with other bioimpedance measurement devices
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess regional distribution of pulmonary perfusion | within 24 hours | To evaluate the effect of epidural block on pulmonary blood flow distribution. |
| Assess oxygenation status | within 24 hours | To evaluate the effect of epidural block by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated. |
Countries
China
Contacts
Primary ContactMing Zhong, MD, phD
Outcome results
None listed