Kidney Stone
Conditions
Brief summary
In clinical practice, many patients are not able to modify their habits to achieve a high level of diuresis and fluid intake and therefore are at an elevated risk for stone recurrence. The investigators think that Ure-Na (osmotic agent) taking could help to increase urine volume and decrease urine concentration, which would be of benefit in the prevention of kidney stones.
Interventions
DRUGUre-Na
* Participants in the study will receive Oral Urea (Ure-Na) treatment at a dose of 30 grams per day (2 x 15 gram pouches per day) * Treatment will continue for approximately 1 month.
Sponsors
Centre hospitalier de l'Université de Montréal (CHUM)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* 18 to 60 years of age * High risk for recurrence (1 or more of) Bilateral or complex stones, Recurrent stones, Family history (1st degree relative), Non-calcium stones, Solitary kidney or anatomical abnormality, Nephrocalcinosis, Systemic disease with risk of stones (tubular acidosis, cystinuria, etc.) * Diuresis \< 1.8 L/24 hours despite recommendations from physicians and/or nutritionist at the kidney stone clinic (as documented in the previous 6 months)
Exclusion criteria
* Patient does not meet 1 of the 3 inclusion criteria * Pregnancy or breastfeeding * Lack of understanding about the protocol and effects of Ure-Na * Expected inability to adequately increase fluid intake on Ure-Na
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change From Baseline in urine output at 1 week and 1 Month | 1 week and 1 month | variation in 24-hour diuresis and urine biochemistry |
Countries
Canada
Outcome results
None listed