Postoperative Nausea and Vomiting
Conditions
Brief summary
The aim of this study to assess which time and dose of dextrose solution more effective in decreasing postoperative nausea and vomiting.
Detailed description
All patients signed informed consent after excluding patients not candidate for the study.patients were divided to three groups, taking either 0.9% saline as control group(group C), dextrose 5%(group D5) or dextrose 10%(group D10).
Interventions
OTHERDextrose 5% in water
One hour before operation, patients were given dexrose 5%100/hour only for 2 hours to end at about middle of surgery
OTHERDextrose 10%
One hour before operation, patients were given dexrose 10 %100/hour only for 2 hours to end at about middle of surgery
OTHERSaline placebo
One hour before operation, patients were given normal saline100/hour only for 2 hours to end at about middle of surgery
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Female non-smokers adults (age 18-65 years) * ASA I-II who were listed for elective surgery under general anesthesia (surgery which is risk for PONV).
Exclusion criteria
* Severe hypertension * Coagulopathy * Significant hepatic or renal disease * Diabetes mellitus or abnormal blood glucose on the morning of surgery * Withdrawal of consent * Severe intraoperative hypotension requiring large volume intravascular fluid treatment * Protocol violations including nitrous oxide administration.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative nausea and vomiting within 24 hour | 24hour after surgery | Number of participants who experienced PONV grade ≥2 as assessed by PONV score . The PACU nurses assessed and documented PONV using a Verbal Descriptive Scale, which correlates to visual analog nausea scores, with an objective measure of severity: 0 = no PONV: patient reports no nausea and has had no emesis episodes; 1 = mild PONV: patient reports nausea but declines antiemetic treatment; 2 = moderate PONV: patient reports nausea and accepts antiemetic treatment; and 3 = severe PONV: nausea with any emesis episode (retching or vomiting). The score was obtained at 0, 30, 60, 90, and 120 minutes after PACU arrival; thus 5 scores were recorded during PACU stay. A 24-hour PONV assessment that elicited any nausea and emesis episode since PACU discharge was obtained by a blinded investigator by telephone or in person at the patient's bedside (delayed PONV). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of doses of antiemetics required to control PONV. | 24hour postoperative | Frequency of doses of antiemetics required to control postoperative nausea and vomiting, initial antiemetic treatment was 10 mg slow IV metoclopramide for occurred nausea or 4 mg IV ondansetron for occurred nausea & vomiting or if the previous treatment failed for nausea |
| Number of classes of antiemetics | 24 hour postoperative | Frequency of classes of antiemetics required to control postoperative nausea and vomiting, Initial antiemetic treatment was 10 mg slow IV metoclopramide for occurred nausea or 4 mg IV ondansetron for occurred nausea & vomiting or if the previous treatment failed for nausea |
Countries
Egypt
Outcome results
None listed