Determine the Effect of Prone Positioning in Adults With ARDS by Electrical Impedance Tomography

Determine the Effect of Prone Positioning on Lung Ventilation and Perfusion Distribution in Adults With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04725227

Enrollment

Registered

2021-01-26

Start date

2020-12-01

Completion date

2022-12-31

Last updated

2021-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS, Electrical Impedance Tomography, Prone Position

Brief summary

determine the effect of prone positioning on ventilation and perfusion distribution in adults with acute respiratory distress syndrome by electrical impedance tomography

Detailed description

By intravenous injection of a small amount of normal saline, electrical impedance tomography enables evaluation of the pulmonary blood flow. EIT might be helpful in establishing the hypoxemia etiology at bedside via combining regional ventilation and perfusion information. The objective of this study was to describe the physiological effects of prone position on respiratory mechanics, ventilation and pulmonary perfusion in patients with ARDS.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* patients who were undergoing mechanical ventilation with moderate-to-severe ARDS (defined as a Pao2:Fio2 ratio \< 150 mm Hg with a positive end-expiratory pressure ≥ 5 cm of water, and an Fio2 of ≥ 0.6) according to the Berlin definition

Exclusion criteria

* contraindications to the use of EIT (e.g., presence of pacemaker or chest surgical wounds dressing)

Design outcomes

Primary

Measure	Time frame	Description
Assess regional distribution of pulmonary perfusion	within 24 hours	To evaluate the effect of prone positon on pulmonary blood flow distribution.
Assess regional distribution of pulmonary ventilation	within 24 hours	To evaluate the effect of prone positon on pulmonary vetilation distribution.
Assess oxygenation status	within 24 hours	To evaluate the effect of prone position by assessing regional distribution of pulmonary perfusion based on indicator dilution and changes at different points in time during varying states of regional ventilation will be evaluated.

Countries

China

Contacts

Primary ContactMing Zhong, MD, phD

zhong.ming@zs-hospital.sh.cn021-65642662

Outcome results