Pancreaticogastrostomy for High-Risk Pancreas

Double Purse-String Telescoped Pancreaticogastrostomy for High Risk Anastomosis: A 6-Year Single Center Case-Controlled Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04724174

Acronym

GASTROPAN

Enrollment

198

Registered

2021-01-26

Start date

2013-06-01

Completion date

2020-01-31

Last updated

2021-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anastomosis; Complications, Pancreatic Fistula

Keywords

High Risk Pancreatic Anastomosis, Clinically Relevant Pancreatic Fistula, Pancreaticogastrostomy

Brief summary

In 2013, a double purse-string telescoped pancreaticogastrostomy (PG) technique appeared to significantly reduce the risk of postoperative pancreatic fistula (POPF). This study compared the incidence of clinically relevant POPF in patients with high-risk anastomosis after undergoing PG or pancreaticojejunostomy (PJ) techniques.

Detailed description

From 2013 to 2019, consecutive patients with high-risk anastomosis (i.e., updated alternative-Fistula Risk Score (ua-FRS) \>20%) underwent pancreatoduodenectomy with either the PJ or PG technique. Optimal mitigation strategy (external stenting and octreotide omission) was applied for all patients. The primary endpoint of the study was the incidence of clinically relevant POPF. Data were entered prospectively into an institutional clinical database (NCT02871336).

Interventions

PROCEDUREpancreaticogastrostomy

Pancreaticogastrostomy technique was performed according to the precise description of Addeo et al.

PROCEDUREpancreaticojejunostomy

Pancreaticojejunostomy technique was performed using the 5/0 polypropylene interrupted monofilament suture in a one-layered duct-to-mucosa end-to-side anastomosis (Cattell-Warren anastomosis).

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Pancreatoduodenectomy * High updated alternative -Fistula Risk Score which was defined \> 20%, as the higher-risk category of the alternative-Fistula Risk Score

Exclusion criteria

* Explorative laparotomy * Hard pancreatic parenchyma

Design outcomes

Primary

Measure	Time frame	Description
Incidence of clinically relevant post operative pancreatic fistula	at hospital discharge assessed up to 30 days	clinically relevant post operative pancreatic fistula according to the 2016 International Study Group of Pancreatic Surgery (ISGPS) definition

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026