Head and Neck Squamous Cell Carcinoma
Conditions
Keywords
Oxygen enhanced MRI
Brief summary
Assessment of the use of oxygen enhanced MRI scanning in a cohort of patients with head and neck squamous cell carcinomas to identify areas of hypoxia with tumours and relate this to treatment outcomes.
Detailed description
Oxygen-enhanced MRI (OE-MRI) is a technique being actively investigated for imaging hypoxia within cancer tissues. Preliminary clinical data demonstrates the feasibility of using this methodology to study patients with head and neck squamous cell carcinoma (HNSCC). The investigators wish to investigate using this methodology to identify hypoxic subvolumes within HNSCC that may have greater resistance to standard radiotherapy treatment and investigate the association of such hypoxic regions with treatment outcomes.
Interventions
DIAGNOSTIC_TESTOxygen Enhanced MRI scan
Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.
Sponsors
Nottingham University Hospitals NHS Trust
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
Yes
Inclusion criteria
Non-patient Volunteer Inclusion Criteria: * Age 18 years and above * Signed written informed consent Patient Inclusion Criteria: * Histologically proven or strong clinical suspicion of squamous cell carcinoma of the head and neck * Suitable for undergoing radical radiotherapy or chemoradiotherapy according to local protocols within the head and neck Cancer MDT * Age 18 years and above * Adequate physical fitness (WHO performance status 0 to 2) * Signed written informed consent
Exclusion criteria
Non-patient Volunteer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of patients with areas detected within tumours of the head and neck area that have measurable hypoxia using OE-MRI technique. | 2 years | Feasibility of OE-MRI scans to detect hypoxic areas within tumours in patients with head and neck squamous cell carcinomas |
| Association with treatment failure | 2 years | Test predictive value of OE-MRI to identify patients with the highest risk of treatment failure and provide data to allow a power calculation for a larger future trial of the predictive power of OE-MRI for treatment outcomes in head and neck cancer treated with radiotherapy. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tumour perfusion | 2 years | Assessment of routinely used diagnostic MRI images to identify non-perfused parts of tumours in combination with oxygen maps |
Countries
United Kingdom
Outcome results
None listed