Localized Aggressive Periodontitis
Conditions
Keywords
Nigella Sativa oil extract, Localized Aggressive Periodontitis
Brief summary
The aim of this study will be to evaluate, clinically, and radiographically the effect of Nigella Sativa oil extract Mixed with xenograft versus xenograft alone in the treatment of intra-bony defects in patients with aggressive periodontitis.
Detailed description
in 10 patients, twenty sites in subjects with, localized aggressive periodontitis, with CAL ≥ 5 will be included in the present study. Sites will be allocated randomly to be surgically treated with, Nigella Sativa oil extract Mixed with xenograft or xenograft alone. At baseline, 3, 6 after surgery, the following clinical parameters (PD, CAL, BOP) and CBCT at baseline and 6 months x-ray will be recorded.
Interventions
PROCEDUREperiodontal regenerative surgery
Procedure/Surgery: open flap debridement Open flap for removal of diseased periodontal tissues and necrotic cementum , using xenogenic bone graft with or without Nigella Sativa oil extract
Sponsors
Tanta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Intervention model description
10 patients, twenty sites with, localized aggressive periodontitis, with CAL ≥ 5 will be included in the present study. Sites will be allocated randomly to be surgically treated with, Nigella Sativa oil extract Mixed with xenograft or xenograft alone.
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* systemically healthy patients were selected * patients who had not received any medications for the previous six months that may interfere with periodontal tissue health or healing. * Patients should demonstrate their ability to maintain good oral hygiene
Exclusion criteria
* • Smokers and pregnant patients. * Medically compromised patients and systemic conditions precluding periodontal surgery. * Subjects who do not comply with oral hygiene measures as evidenced in recall visits. * Restoration or caries in the site to be treated or non-vital tooth * Restoration or caries in the site to be treated or non-vital tooth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| probing pocket depth | 6 months | probing pocket depth probing pocket depth will be recorded at baseline, 3, and 6 months at the site to be treated |
| clinical attachment level | 6 months | clinical attachment level will be recorded at baseline, 3, and 6 months at the site to be treated |
| bleeding on probing | 6 months | bleeding on probing will be recorded at baseline, 3, and 6 months at the site to be treated |
| cone beam x ray measuring bone fill | 6 months | bone fill will be recorded at baseline, and 6 months at the site to be treated |
Countries
Egypt
Outcome results
None listed