The Need of Revisiting to an Outpatient Clinic After the Prescription of Vonoprazan or Esomeprazole

The Need of Revisiting to an Outpatient Clinic After the Prescription of Vonoprazan or Esomeprazole for 4weeks for Erosive Esophagitis Without Any Appointments

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04720781

Enrollment

300

Registered

2021-01-22

Start date

2021-01-21

Completion date

2024-12-31

Last updated

2025-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroesophageal Reflux

Brief summary

After vonoprazan (20mg/day) or esomeprazole (20mg/day) for 4weeks is prescribed for patients with erosive esophagitis diagnosed by esophagogastroduodenoscopy, the number of patients who will visit our outpatient clinic again due to some reasons without any appointments is compared with vonoprazan group and esomeprazole.

Detailed description

1. Patients who have erosive esophagitis diagnosed by esophagogastroduodenoscopy is enrolled. 2. Vonoprazan (20mg/day) or esomeprazole (20mg/day) is prescribed for 4weeks the patients randomly without next appointments. 3. Some patients may visit our outpatient clinic again due to some reasons without any appointments. 4. The number of the patients who revisit our outpatient clinic again is compared with vonoprazan group and esomeprazole.

Interventions

DRUGVonoprazan

Vonoprazan (20mg/day) is prescribed for 4 weeks.

DRUGEsomeprazole

esomeprazole (20mg/day)

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

19 Years to 100 Years

Healthy volunteers

Inclusion criteria

* outpatients belonging to American Society of Anesthesiologists class I or II * patients have erosive esophagitis diagnosed by esophagogastroduodenoscopy shortly before the prescription

Exclusion criteria

* other acid blockers are taken

Design outcomes

Primary

Measure	Time frame	Description
The number of patients who revisit our outpatient clinic after the prescription without any appointments	3 months	The need to revisit our outpatient clinic again without any appointments may show the patients' satisfaction or dissatisfaction after the prescription of vonoprazan or esomeprazole. The difference in the number between the two groups may show the difference in the effectiveness between the two medicines.

Secondary

Measure	Time frame	Description
Change of the main symptom with patients after/before medication when the patients revisit again	3 months	The ratio of the degree of the main symptom after/before taking the medicine Good 0%- Bad 100%

Other

Measure	Time frame	Description
Questionnaire on satisfaction with taking the medicine at revisiting	3months	The patient's satisfaction is assessed using visual analogue scale (Exellent 100% to very bad 0%).

Countries

Japan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026