Aortic Valve Disease, Aortic Valve Stenosis
Conditions
Keywords
calcific aortic valve disease, valvular heart disease, inflammation, innate immune cells
Brief summary
Investigators plan to characterize systemic inflammation and circulating immune cells in participants with moderate and severe calcific aortic valve disease and matched healthy controls.
Detailed description
Calcific aortic valve disease (CAVD) is the most common type of valvular heart disease in the Western world. Due to the aging of the population, the impact of this disorder is expected to further increase in the next decades. The underlying pathophysiology remains incompletely defined and there are currently no effective medical treatments capable of altering its course, identifying a major unmet need in this growing population of patients. Based on the similarities between CAVD and atherosclerosis in pathophysiology and shared risk factors, it is now hypothesized that activation of the innate immune system contributes to the development of CAVD. Therefore, the investigators will perform an observational study to assess the role of activation of the innate immune system in CAVD.
Interventions
OTHERBlood drawing
Blood will be drawn after inclusion of the participants.
Sponsors
Radboud University Medical Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Age \> 18 years * Mild, moderate or severe degenerative aortic valve stenosis as defined by transthoracic echocardiography according to the 2017 ESC/EACTS guidelines for the management of valvular heart disease.
Exclusion criteria
* Active auto-inflammatory or auto-immune diseases * Anti-inflammatory drugs * Vaccination less than one month before inclusion * Bone marrow transplantation * Active malignancy, except for local basal cell carcinoma or local squamous cell skin carcinoma, that can be treated curatively by excision. * History of endocarditis of the aortic valve * History of radiation therapy aimed at the chest * Acute ischemic cardiac event less than three months before inclusion * Systemic inflammation less than one month before inclusion with fever and/or for which antibiotics have been prescribed, with the exception for the use of nitrofurantoin for a urinary tract infection without fever
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory phenotype of circulating immune cells. | 2 years | The inflammatory phenotype of circulating immune cells will be measured by determining the cytokine production capacity after stimulation with relevant stimuli. |
Countries
Netherlands
Contacts
Primary ContactNiels P. Riksen, prof. dr.
Outcome results
None listed