Sepsis, Septic Shock
Conditions
Keywords
sepsis, septic shock, angiotensin II
Brief summary
Evaluation of plasma angiotensin II and angiotensin II receptor levels in patients with sepsis and septic shock: a prospective observational study.
Detailed description
There is an increasing number of experimental publications investigated effects of angiotensin II and receptors on the pathogenesis and treatment of sepsis and septic shock. However, its level in humans and its relationship with the severity of the disease has not been investigated. If angiotensin II plays a role in the diagnosis and prognosis of septic shock by evaluating this relationship in our study, it may be a biomarker to be used in future diagnosis, prediction of prognosis and treatment. This will enable early recognition and treatment of this disease, which causes high mortality and cost in intensive care units, thus increasing the survival rate and reducing the cost.
Interventions
None listed
Sponsors
Inonu University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* intensive care unit patient
Exclusion criteria
* End-stage organ failure, * immunodeficiency, vasospastic disease, pregnancy, other shock causes (hypovolemic, cardiogenic, neurogenic) a life expectancy of less than 48 hours
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| angiotensin II levels | 0-3 days | serum angiotensin II levels |
| angiotensin II receptor I | 0-3 days | serum angiotensin II receptor I levels |
| angiotensin II receptor II | 0-3 days | serum angiotensin II receptor II levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mortality | 28 days | mortality rate |
| crp level | 0-3 days | crp levels |
| procalsitonine level | 0-3 days | Procalsitonine level |
Countries
Turkey (Türkiye)
Outcome results
None listed