Covid19
Conditions
Keywords
Covid19, Long term outcomes, Chest computed comography, Pulmonary functional tests, Exercise capacity, Quality of life
Brief summary
The investigators hypothese that lung involvement due to COVID-19 may cause structural changes in the lung in the long term. In this study the effects of structural changes in the lung on pulmonary function tests, exercise capacity and quality of life will be examined.
Detailed description
Coronavirus disease-19 (COVID-19) has a clinical spectrum ranging from asymptomatic cases to severe cases requiring intensive care hospitalization due to respiratory failure. The disease mostly infects the lower respiratory tract. Typical computed tomography findings of lung involvement are bilateral, peripherally located ground glass density and consolidations. There is a close relationship between tomography findings and clinical severity. It is not known whether there will be complete recovery in the lungs. Investigators will evaluate pulmonary structures with chest computed tomography, respiratory capacity with pulmonary function tests (PFTs), exercise capacity with six minutes walk test and quality of life with short form-36 (SF-36) im patients who survivors of COVID-19 at least 6 months after hospital discharge.
Interventions
DIAGNOSTIC_TESTChest Computed Tomography
Evaluation of Lung Structure
DIAGNOSTIC_TESTPulmonary Function Tests
Respiratory Capacity
Exercise Capacity
OTHERQuality of Life
Physical disability assessment tool
Sponsors
Turkish Respiratory Society
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients who were ≥18 years * COVID-19 confirmed by Real-Time PCR * At least 6 months after discharge
Exclusion criteria
* Patients who were \< 18 years * Pregnancy * Become bedridden after discharge
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Structural Change in Lung | up to 6 months after discharge | Chest Computed Tomography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Carbon monoxide diffusion capacity (DLCO) | up to 6 months after discharge | Carbon monoxide diffusion capacity of the lung |
| Exercise Capacity | up to 6 months after discharge | Six Minutes Walking Test |
| Short Form Health Survey Score (SF-16) | up to 6 months after discharge | A 36-item patient-reported questionnaire that covers eight health domains: physical functioning (10 items), bodily pain (2 items), role limitations due to physical health problems (4 items), role limitations due to personal or emotional problems (4 items), emotional well-being (5 items), social functioning (2 items), energy/fatigue (4 items), and general health perceptions (5 items). Scores for each domain range from 0 to 100, with a higher score defining a more favorable health state |
Countries
Turkey (Türkiye)
Outcome results
None listed