Covid19, SARS-CoV Infection
Conditions
Keywords
endothelial function, flow-mediated dilation, vascular function, carotid intima-media thickness
Brief summary
This study will evaluate the associations between vascular parameters and clinical outcomes in patients hospitalized with COVID-19. The vascular function and structure of individuals with COVID-19 admitted to the General Hospital of the University of Sao Paulo will be assessed in the first 72 hours of hospitalization. Then, participants will be followed up until hospital discharge/death. Logistical regressions will be run to evaluate if vascular function/structure can predict ICU admissions, intubation, thrombosis or death.
Detailed description
This is a prospective cohort study conducted at the General Hospital of the University of São Paulo Medical School (HCFMUSP). Male and female participants with SARS-CoV-2 and recently admitted to the hospital (≤ 72 hours) will be recruited at the emergency department and outpatient clinics at the HCFMUSP. Immediately upon recruitment, participants will perform the assessment of flow mediated dilation of the brachial artery and the assessment of carotid intima-media thickness. Subsequently, they will be followed during the entire period of hospitalization. The present study will employ as primary endpoint a composite of ICU admission, intubation or mortality during the period of hospitalization. Cardiovascular complications, such as arterial (AE), deep venous (DVP) or pulmonary embolism (PE) , acute myocardial infarction (AMI), stroke, cardiac arrest, atrial fibrillation and acute kidney injury will be considered secondary endpoints. The association between the vascular parameters and clinical outcomes will be examined by a multivariate logistic regression.
Interventions
None listed
Sponsors
University of Sao Paulo General Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with SARS-CoV-2 * Recently admitted to the hospital (≤ 72 hours) * Not yet proceeded to ICU care
Exclusion criteria
* Patients transferred from other hospitals * Participants in delirium state * Participants with a recent history of endotracheal intubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Composite outcome | Up to hospital discharge, an average of 4 weeks | A composite outcome including ICU admission, intubation and all-cause mortality |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | Up to hospital discharge, an average of 4 weeks | All-cause mortality rate along the study |
| ICU admission | Up to hospital discharge, an average of 4 weeks | Admission to the ICU along the study |
| Intubation | Up to hospital discharge, an average of 4 weeks | Necessity of intubation along the study |
| Cardiovascular complications | Up to hospital discharge, an average of 4 weeks | Cardiovascular complications, such as arterial, deep venous or pulmonary embolism, acute myocardial infarction, stroke, cardiac arrest, atrial fibrillation and acute kidney injury |
Countries
Brazil
Contacts
Primary ContactTiago Peçanha, PhD
Outcome results
None listed