Covid19, Hiv
Conditions
Brief summary
Contradicting preliminary results are available on the impact of COVID-19 in people with HIV (PWH). How achieving goals of the HIV 90-90-90 cascade of care influences the risk of COVID-19 in PWH is unclear. The primary objective is to determine the impact of COVID-19 in PWH cohorts from Ukraine and the Netherlands.
Interventions
None listed
Sponsors
Lviv Regional AIDS Health Center
Erasmus Medical Center
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
HIV infected No registered objection to use of data
Exclusion criteria
None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence COVID19 | Up to 2 years | Prevalence (percent) of clinical COVID-19 in PWH cohorts from Ukraine and in the Netherlands. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| WHO categories COVID-19 | Up to 2 years | Prevalence of no suspicion, possible, probable and proven COVID-19 cases in the past 6 months PWH cohorts from Ukraine and the Netherlands. |
| WHO disease severity COVID-19 | Up to 2 years | Proportion of COVID-19 patients according to the severity of COVID-19 on an adapted World Health Organisation 5 point disease severity scale (where 1=no symptoms, 2=symptoms but outpatient, 3=admitted to hospital, 4=admitted to ICU, 5=fatal) in people with HIV cohorts from Ukraine and the Netherlands. |
| Seroprevalence | Up to 2 years | Anti-SARSCOV2 seroprevalence in PWH cohorts from Ukraine and the Netherlands |
| NPV/PPV WHO categories COVID19 | Up to 2 years | Positive and negative predictive value of the WHO COVID-19 case probability categories on anti-SARSCOV2 serology in PWH cohort from Ukraine |
| Treatment | Up to 2 years | Description of COVID-19 therapeutic management in PWH cohorts from Ukraine and the Netherlands |
| Predictors for COVID-19 | Up to 2 years | Predictor variables for having clinical COVID-19 in PWH cohorts from Ukraine and the Netherlands according to 1) sex, 2) age categories (\<50, 50-70, \>70), 3) ART (LPV/r vs other and TDF containing vs non-TDF containing regimens), 4) most recent CD4+T-cell 5) HIV-RNA suppressed (\<=50 / \>50), 6) prior TB, 7) prior BCG, 8) HIV transmission group, 9) comorbidities (0 vs 1 vs \>1). |
| Predictors for COVID-19 severity | Up to 2 years | Predictor variables for the highest score on an ordinal scale for COVID-19 severity according to the adapted 5point WHO severity scale (where 1=no symptoms, 2=symptoms but outpatient, 3=admitted to hospital, 4=admitted to ICU, 5=fatal) in PWH cohorts from Ukraine and the Netherlands according to 1) sex, 2) age categories (\<50, 50-70, \>70), 3) ART (LPV/r vs other and TDF containing vs non-TDF containing regimens), 4) most recent CD4+T-cell 5) HIV-RNA suppressed (\<=50 / \>50), 6) prior TB, 7) prior BCG, 8) HIV transmission group, 9) comorbidities (0 vs 1 vs \>1) |
| Incidence COVID-19 | Up to 2 years | Incidence (nr cases/person years) of clinical COVID-19 cases in PWH cohorts from Ukraine and in the Netherlands |
Other
| Measure | Time frame | Description |
|---|---|---|
| Effect of socio-economic status by questionnaire on COVID-19 incidence | Up to 2 years | Evaluate the impact of social economic status on COVID-19 incidence. |
| Effect of socio-economic status on COVID-19 severity | Up to 2 years | Evaluate the impact of social economic status on COVID-19 severity according to WHO 5 point scale (where 1=no symptoms, 2=symptoms but outpatient, 3=admitted to hospital, 4=admitted to ICU, 5=fatal) |
| Symptoms | Up to 2 years | Describe symptoms associated with COVID probability in PWH cohorts from Ukraine and the Netherlands |
| Rapid Ag test | Up to 2 years | Evaluate the PPV/NPV of the rapid antigen test in PWH with symptoms suspected of COVID-19 in Ukraine and the Netherlands |
| PPV/NPV WHO categories COVID-19 | Up to 2 years | Positive and negative predictive value of the WHO COVID-19 case probability categories in the prior 3 months on anti-SARSCOV2 serology in PWH cohort from Ukraine |
| HIV vs non-HIV | Up to 2 years | Correlation of HIV status with the highest score on an ordinal scale for COVID-19 severity according to the adapted 5point WHO severity scale (where 1=no symptoms, 2=symptoms but outpatient, 3=admitted to hospital, 4=admitted to ICU, 5=fatal) in matched PWH cases with HIV uninfected controls by age, sex and comorbidities. |
Countries
Netherlands, Ukraine
Outcome results
None listed