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The Association Between Sedentary Behaviour and Cardiometabolic Health in Trained Athletes

Do Trained Athletes Also Suffer From the Sedentary Behaviour Paradigm?: the Association Between Sedentary Behaviour and Cardiometabolic Health

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04711928
Acronym
HPAC
Enrollment
60
Registered
2021-01-15
Start date
2021-01-10
Completion date
2021-10-01
Last updated
2022-03-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Athletes, Cardiometabolic Health, Physical Activity, Sedentary Behavior

Brief summary

Physical inactivity is one of the major contributing factors for the development of chronic diseases and highly correlated with increased all-cause mortality. In the last decade an exponential growth in research concerned with the study of sedentary behaviour and the potential for detrimental effects on health have been published. In this field increasing evidence suggests that prolonged periods of sedentary time, independent of the amount of physical activity, also increases the risk for the development of several chronic conditions and all-cause mortality. Here, sedentary behaviour is defined as any waking behaviour, characterized by a low energy expenditure (≤1.5 METs), while being in a sitting or reclining posture. Interestingly, the advised moderate-to-vigorous bouts of exercise recommended by the various guidelines cannot compensate the negative impact on health risks arising from prolonged periods of sitting. In other words, it seems that people compensate their total amount of physical activity after exercise training by decreasing their physical activity levels throughout the rest of the day. Here, it appears that frequent, even low-intensity interruptions of periods of sitting are required for good cardiometabolic health. Therefore, not only physical activity but also prolonged sitting should be targeted to optimize cardiometabolic health. Nevertheless, a recent harmonized meta-syntheses indicated that the association between self-reported sitting with all-cause and cardiovascular disease mortality are only partially independent of physical activity, but were particularly evident in those who undertake insufficient physical activity (\<150min/week). However, it is unclear whether high amounts of objectively measured physical activity attenuates or even eliminates the detrimental effects of prolonged sitting. In addition, it is still unclear whether high amounts of physical activity can preserve a healthy cardiometabolic risk profile, despite prolonged sitting. Therefore, in this study we want to investigate the association between sedentary behaviour, physical activity and cardiometabolic health in highly physically active adults.

Interventions

BEHAVIORALPhysical activity and sedentary behaviour

Athletes with a high physical activity and a low or high sedentary time

Sponsors

Hasselt University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years

Inclusion criteria

* Active individuals with at least 4 training hours per week

Exclusion criteria

* pregnancy * Any known contradiction for physical activity * Systolic blood pressure \>160mmHg, diastolic blood pressure \>100mmHg * More than 20 alcohol consumptions per week * Participants diagnosed with any known chronic disease

Design outcomes

Primary

MeasureTime frameDescription
Sedentary time (min/day)day 1Main outcome parameter of sedentary behaviour indication measured with ActivPAL3

Secondary

MeasureTime frameDescription
Light physical activity time (min/day)day 1Physical activity parameter measured with ActivPAL3
Blood glucose concentrationday 1Parameter of glucose homeostatis
Blood insulin concentrationday1Parameter of glucose homeostatis
Blood total cholesterol concentrationday 1Parameter of lipid metabolism
Blood triglyceride concentrationday 1Parameter of lipid metabolism
Blood high density lipoprotein concentrationday 1Parameter of lipid metabolism
Moderate-to-vigorous physical activity time (min/day)day 1Physical activity parameter measured with ActivPAL3
Fat mass (kg)day 1Parameter of body composition measured with DEXA-scan
Lean mass (kg)day 1Parameter of body composition measured with DEXA-scan
Systolic blood pressureday 1Parameter of cardiovascular health
Diastolic blood pressureday 1Parameter of cardiovascular health
Maximal oxygen uptakeday 1Parameter of oxygen capacity measured with cardiopulmonary exercise testing
Blood low density lipoprotein concentrationday 1Parameter of lipid metabolism

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 11, 2026