Acute Aortic Syndrome, Type a Aortic Dissection
Conditions
Keywords
Acute Aortic Syndrome
Brief summary
Acute Aortic Syndrome (AAS) is a common feature of acute aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Ulinastatin has antiinflammatory activity and suppresses the infiltration of neutrophils and the release of elastase and chemical mediators from neutrophils. Recent studies have shown that ulinastatin may be cytoprotective against ischemia-reperfusion injury in the liver, kidney, heart, and lung. The authors aim to examine the association between decreased release of inflammatory response to urinary trypsin inhibitor treatment and decreased myocardial and lung injury after acute aortic syndrome surgery.
Interventions
DRUGUlinastatin
Ulinastatin is taken three times a day.
DRUGBlank control
Blank control
Sponsors
Beijing Anzhen Hospital
Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* The patients are conformed to 2010 ACC/AHA guidelines for the diagnosis and treatment of thoracic aortic disease (TAD) within two weeks of onset; * Patients with type a acute aortic syndrome confirmed clinically and radiologically and planning to undergo aortic surgery were enrolled. * The patients' age of 18 years or older. * Agree to participate in the study and sign the informed consent.
Exclusion criteria
* Patients allergic to Ulinastatin; * Lactating women and pregnant women; * Patients with mental diseases; * Refuse to participate in this study and refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SOFA score | mean SOFA score 7 days after surgery | The daily SOFA score after baseline was calculated for each patient on the basis of organ systems: neurologic, cardiovascular, respiratory, renal, hepatic, and coagulation systems. (Scores for each system range from 0 to 4, with higher scores indicating more severe organ-system dysfunction) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality | 30 days after surgery | Death from any cause |
Countries
China
Outcome results
None listed