Hematopoiesis, Pulmonary Embolism
Conditions
Keywords
Pulmonary Embolism, hematopoiesis, genetic sequencing, endothelial dysfunction
Brief summary
The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.
Interventions
BIOLOGICALblood sample
Blood sample withdrawal in order to perform DNA sequencing
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening. * For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening.
Exclusion criteria
* Age superior to 65 years old, * Active cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Variation of CHIP markers between patients groups | up to 2 years | Variation of CHIP markers (clonal hematopoiesis of indetermined prognosis ) between patients groups. CHIP concept have been defined as a mutation of preleukemic genes at an allelic variation inferior to 2% associated with normal complete blood count. |
Countries
France
Contacts
Primary ContactSimon SOUDET, MD
Outcome results
None listed