Critically Ill
Conditions
Keywords
ventilator, weaning, microcirculation
Brief summary
Weaning ventilator support in critically ill patients is crucial. Both delayed extubation and unexpected early reintubation are harmful to the patients. Weaning parameters and spontaneous breathing trial are used to investigate the indication and predict the successful extubation. Hemodynamic stability and physical reserve are important indicators as well. Microcirculation parameters are known to be more sensitive to the change of hemodynamic status than macrocirculation parameters. We hypothesize that the change of sublingual microcirculation before and after spontaneous breathing trial is different between the the patients with successful extubation and the patients with failed extubation. Thus, this study measures sublingual microcirculation in patients receiving spontaneous breathing trial and record the extubation status (successful or failed). The microcirculation parameters before and after spontaneous breathing trial are compared between the the patients with successful extubation and the patients with failed extubation.
Interventions
Sublingual microcirculation images were recorded using an incident dark-field video microscope
Sponsors
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* critically ill patients received ventilator longer than 12 hours * ready for spontaneous breathing trial * GCS coma score equal or higher than 8
Exclusion criteria
* aged less than 20 years * patient with tracheostomy * patient and patients' relatives are non-native speakers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Initial total vessel density | 0 hour | Total vessel density measured by Cytocam before and after spontaneous breathing trial |
| Change of total vessel density | baseline and 1 hour | The difference between the total vessel density measure by Cytocam before and after spontaneous breathing trial |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Initial perfused vessel density | 0 hour | Perfused vessel density measured by Cytocam before spontaneous breathing trial |
| Change of perfused vessel density | baseline and 1 hour | The difference between the perfused vessel density measure by Cytocam before and after spontaneous breathing trial |
Countries
Taiwan
Outcome results
None listed