The Effects of Different Lipid Emulsions on the Adipokines in Critically Ill Patients With Sepsis

The Effects of Different Lipid Emulsions on the Adipokines, Inflammatory Markers and Mortality in Critically Ill Patients With Sepsis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04711564

Enrollment

Registered

2021-01-15

Start date

2018-03-29

Completion date

2020-04-15

Last updated

2021-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

Parenteral Nutrition, Sepsis, Adipokines, Inflammation, Intensive Care

Brief summary

Intravenous lipid emulsions contain a number of biologically active ingredients, but the most important are fatty acids. Different fatty acids can affect a number of different physiological processes in different ways in critically ill patients. Adipose tissue can play an important role in metabolic changes of critical illnesses and in adaptation to stress through structural as well as functional changes Although it is known that serum adipokine and cytokine response changes in critical sepsis patients, the factors affecting these changes and the metabolic consequences of these changes are not well defined. The aim of this study was to evaluate the effects of intravenous lipid emulsions on serum adipokine and cytokine levels in patients with sepsis. Secondly, this is to determine the adipokine and cytokine kinetics in the sepsis process and their relationship with mortality in patients with sepsis.

Interventions

OTHEROlive oil-based intravenous fat emulsions

Parenteral nutrition planned according to the requirements of the patients is given for ten days.

OTHERSoybean-based intravenous fat emulsions

Parenteral nutrition planned according to the requirements of the patients is given for ten days.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Diagnosis of sepsis within the last 24 h * Age above 18 and below 85 years * Indication of only parenteral nutrition therapy

Exclusion criteria

* Planning any different medical nutrition therapy such as enteral nutrition, immunonutrition or oral nutrition * Hypersensitivity (fish, egg or soy protein) * Uncontrolled hemorrhage * Uncontrolled hyperlipidemia * Severe primary blood coagulation diseases * Acute pancreatitis * Acute thromboembolic diseases * Severe liver failure * RIFLE stage III and IV renal failure * Pregnancy or lactation * Expected stay in ICU not more than 10 days * Expected survival not more than 10 days

Design outcomes

Primary

Measure	Time frame	Description
Change of the adipokine in the first ten days in onset sepsis	Baseline and 10 days	Adipokines levels are assayed using a enzyme-linked immunosorbent assay

Secondary

Measure	Time frame	Description
Intensive care unit length of stay	Time of admission to the ICU until the time of discharge from the intensive care unit, up to 1 year	Time from study inclusion to intensive care unit discharge.
28-day mortality	28 day	Mortality rate

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026