Psoriasis Circinata, Psoriatic Arthritis, Psoriatic Nail, Rheumatoid Arthritis, Spondylarthropathies
Conditions
Keywords
Psoriasis, Psoriatic Arthritis, Psoriatic Nail, Dermoscopy
Brief summary
This study evaluates the fingernail findings of the rheumatoid arthritis, spondylopathy and psoriatic arthritis patient groups with the fingernails of psoriasis patients clinically and dermatoscopically and investigates the benefit of dermoscopy in the differentiation of these patients.
Detailed description
Psoriasis is a common chronic inflammatory disease with many comorbidities. Dermatologists have a very important role in the early diagnosis of psoriatic arthritis, which is one of the most important comorbidities of psoriasis. Therefore, studies have been conducted on many factors predicting the risk of psoriatic arthritis and it has been concluded that nail involvement is closely related to psoriatic arthritis.For this reason, the importance of nail examination in the follow-up of psoriasis patients has increased significantly. Nail examination should be done carefully to predict the risk of developing psoriatic arthritis, especially at the beginning of the disease and subclinical types, and dermoscopy should be used to identify patients who may be clinically uncertain. In addition, rheumatoid arthritis and spondylopathy patients have a lot in common with psoriatic arthritis patients.In these patients, there is no clear distinction to diagnose joint involvement, and their distinction is mostly based on the presence or absence of skin findings.Nail findings have an important place among this skin findings in the diagnosis of these patients. Based on all these, this study questions the benefit of clinical and dermoscopic examination of nail findings in the early stages to differentiate these patients, as well as comparing the nail findings and revealing the differences and similarities.
Interventions
DIAGNOSTIC_TESTDermoscopic examination
The periungual area, nail plate, subungual area of the patients' fingernails will be examined and images of the lesional nails or target nails will be recorded for comparison.
Sponsors
Bezmialem Vakif University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Psoriasis confirmed by dermatologist. * Rheumatoid arthritis, ankylosing spondylitis confirmed by rheumatologist (newly diagnosed).
Exclusion criteria
* Unable to consent and understand * Patients with confirmed onychomycosis * Patients receiving biological therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparation of clinical features of nails | six months | All of patients' fingernails will be examined clinically and visible nail findings will be noted. Many findings such as onycholysis, pitting, splinter hemorrhage, nail base vascularity, leukonychia etc. will be recorded. Also, the severity of nail involvement in psoriasis patients will be measured by the NAPSI score |
| Comparation of dermoscopic features of nails | six months | All of patients' fingernails will be examined by dermoscopy and nail findings will be noted. Also in particular, vascularization around the nail will be checked and images of all of the findings will be taken. Rheumatoid arthritis and spondylopathy patients with nail findings consistent with psoriasis will be enrolled. |
| NAPSI (Psoriasis Area and Severity index) | six months | All psoriasis patients will be scored on their nails with NAPSI (Psoriasis Area and Severity Index) scoring system. The correlation of PASI and NAPSI will be examined. |
| PASI (Psoriasis Area and Severity Index) | six months | Skin lesions of all psoriasis patients will be scored with the PASI (Psoriasis Area and Severity Index) system. The correlation of PASI and NAPSI will be examined. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Demographic characteristics | through study completion, an average of 6 months | Demographic characteristics of patients will be compared. |
Countries
Turkey (Türkiye)
Outcome results
None listed