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Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation (STN-DBS)

Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation (STN-DBS) Under General Anesthesia for Patients With Parkinson's Disease or Dystonia and Their Correlation With Prognosis

Status
Withdrawn
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04707638
Enrollment
0
Registered
2021-01-13
Start date
2021-01-01
Completion date
2023-01-11
Last updated
2021-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dystonia, Parkinson Disease

Keywords

Parkinson Disease, Dystonia, deep brain stimultation, neurophysiological characteristics

Brief summary

The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and postoperative efficacy will be evaluated.

Detailed description

The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and postoperative efficacy will be evaluated. The intraoperative neuroelectrophysiological signals would be analyzed.

Interventions

OTHERNo intervention used

No intervention used

Sponsors

Huazhong University of Science and Technology
CollaboratorOTHER
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

1. Patients underwentSTN-DBS in neurosurgery department of Wuhan Union Hospital. 2. Patients with Parkinson's disease or dystonia.

Exclusion criteria

1.Patients without enough follow-up length.

Design outcomes

Primary

MeasureTime frameDescription
Unified Parkinson's Disease Rating Scale (UPDRS)Two years postoperativelyUPDRS has four parts: part I (nonmotor experiences of daily living, total score=16); part II (patient motor experience of daily living, total score=52); part III (clinician motor examination, total score=56); part IV (complications, total score=23). The total score of all the four parts is147. Higher scores means a worse outcome.
Burke Fahn Marsden's Dystonia Rating Scales(BFMDRS)Two years postoperativelyBFMDRS has two parts: BFMDRS movement part (BFMDRS-M) and BFMDRS disability part (BFMDRS-D). The total score of BFMDRS-M is 120 and the total score of BFMDRS-D is 30. Higher scores means a worse outcome.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026