Dyslipidemias, Single Nucleotide Polymorphism
Conditions
Keywords
gene polymorphism, vitamin D receptor, vitamin D, lipid, dyslipidemia
Brief summary
The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.
Interventions
OTHERNo intervention.
No intervention.
Sponsors
Sun Yat-sen University
Shenzhen Center for Chronic Disease Control
Study design
Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 81 Years
Healthy volunteers
Yes
Inclusion criteria
* 1\) ≥ 20 years old Han Chinese; * 2\) living in Shenzhen for \> 2 years; * 3\) free of liver diseases, renal diseases, and any cancers in the past 6 months; and * 4\) not in pregnancy for women.
Exclusion criteria
* 1\) had severe organic diseases, * 2\) had acute infection symptoms, allergic diseases, and malignant tumors, * 3\) had a family history of genetic diseases, * 4\) took VD supplements in the past 6 months, * 5\) took medicines to control lipid levels within 12 hours, or * 6\) took diuretics, did strenuous exercise, or overate within 24 hours before the test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SNPs of VDR | 6 months | Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1 |
| lipid profiles | 6 months | Serum concentrations of TG, TC, LDLC, and HDLC |
| 25OHD | 6 months | Plasma 25-hydroxyvitamin D concentration |
Countries
China
Outcome results
None listed