Breast Cancer
Conditions
Keywords
Breast cancer, Sex steroid receptors
Brief summary
Null hypothesis: Histological grade of tumour bears no relation with the status of sex hormone receptors. Alternate hypothesis: Both the histological grade of tumour and expression of sex steroid receptors are directly related to each other The investigators aim to; 1. see the relationship of sex steroid receptors with the histological grade of breast cancer. 2. evaluate the efficacy of steroid receptors as a prognostic factor
Detailed description
Breast cancer accounts for the largest number of deaths amongst the female population worldwide. It is now considered as a systemic disease even if diagnosed at an initial stage, as the clinical behaviour cannot be accurately predicted. Due to this reason, it is subjected to new dimensions of research every day. The aggressiveness of the cancer is directly proportional to the histopathological grade at the time of diagnosis. This is true with reference to the clinical stage at the time of presentation, the probability to metastasize and potential to recur. The idea of steroids receptor expression by the tumour is not new, and to evaluate their status prior to the induction of hormone therapy is a must. The sex steroids, which are produced intratumorally, include estrogen, progesterone, and androgens. They act on their specific receptors present on the cell surface, within the cytoplasm and at the nuclear membrane. It is a measurement of these receptors that decide the potential of an individual to respond to different types of hormones like estrogen receptor blockers and aromatase inhibitors. Do the histological grade of tumour bears some relation with the status of these receptors and can investigators predict and rely just on the cellular behaviour of tumour for the purpose of prognosis is still under investigation. This study is designed to see the relationship between the histopathological grade of the tumour with the expression of sex steroid receptors. It will also try to evaluate whether these receptors bear some prognostic value or not.
Interventions
OTHERNo Intervention
No intervention used. This is observational study
Sponsors
Liaquat University of Medical & Health Sciences
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* All patients diagnosed with breast cancer irrespective of age, gender and clinical stage
Exclusion criteria
* Any patient who lost to follow up
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Histopathology of tumour | 6 months | The incidence of grade and type of breast cancer at the time of study will be recorded and analysed |
| Steroid receptor status | 6 months | The concentrations of estrogen and progesterone receptor will be calculated and analysed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Age | 6 months | The age of patient will be calculated and compared to the primary outcomes. |
| State of menstruation | 6 months | The onset of premenopausal and postmenopausal status of patient will be recorded |
| Stage of tumour | 6 months | The status of clinical and pathological stage of the breast cancer at the time of study will be analysed. |
Countries
Pakistan
Contacts
Primary ContactFazila Hashmi, FCPS
Outcome results
None listed