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MRI Exploration of Meningeal Inflammatory Disease

MRI Exploration of Meningeal Inflammatory Disease

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04707170
Acronym
EIME
Enrollment
302
Registered
2021-01-13
Start date
2021-06-16
Completion date
2023-06-16
Last updated
2023-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MRI

Brief summary

Patients who have agreed to participate in the study will complete the MRI protocol as part of routine care, to which two additional sequences of 6 minutes duration will be added. The MRI of routine care includes at least the following sequences: * 3D T1 TFE 1.0 isotropic (2 minutes) * T2 TSE (2 minutes) * 3D FLAIR pre-injection (opt) (3 minutes) * 3D FLAIR post-injection (3 minutes) As part of the research, the following sequences will be acquired: * FABIR pre-injection (3 minutes) * FABIR post-injection (3 minutes) Patients hospitalized for a foreseeable duration of at least 24 hours will be offered participation in the longitudinal tab of the study, for which four non-injected MRI examinations will be performed. The examinations will be carried out remotely from the injected MRI (1h, 2h, 12h-15h, 24h-36h). These exams dedicated to research will include the following sequences for a maximum of 8 minutes: * 3D T1 TFE 1.0 isotropic (2 minutes) * 3D FLAIR (3 minutes) * FABIR (3 minutes)

Interventions

DEVICEMRI with gadolinium injection

Patients presenting for imaging for whom an MRI examination with gadolinium injection has been prescribed and who meet the inclusion and non-inclusion criteria will be offered to participate in the study. The patients included, hospitalized at the A. de Rothschild Foundation Hospital for at least 24 hours, may be included in the ancillary study to meet secondary objective number 5.

Sponsors

Fondation Ophtalmologique Adolphe de Rothschild
Lead SponsorNETWORK

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Patient over 18 years old * To benefit as part of his treatment of an MRI with injection of gadolinium * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme For the ancillary study to meet secondary endpoint number 5: * Patient over 18 years old * To benefit as part of his treatment of an MRI with injection of gadolinium * Hospitalized for an expected period of at least 48 hours after the time of inclusion * Express consent to participate in the study * Affiliate or beneficiary of a social security scheme

Exclusion criteria

* Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman

Design outcomes

Primary

MeasureTime frame
detection of meningeal contrast enhancement with the flair sequence1 DAY
detection of meningeal contrast enhancement with the FABIR sequence1 day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026