Early Period After Cardiopulmonary Bypass Surgery, Etiology of Hyperlactathemia, Washout Phenomenon
Conditions
Keywords
Early Hyperlactatemia, Cerebral Oxygen Saturation,, Cardiovascular Surgery
Brief summary
Objective: The objective of the study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period.
Detailed description
The objective of the prospective study was to investigate a reverse correlation between blood lactate levels and rSO2, and distinguish between hypoxic and non-hypoxic hyperlactatemia seen in the early postoperative period. Sixty American Society of Anesthesiologists (ASA) II-III patients were included in this study. Perioperative data, including age, weight, body surface area, gender, body temperature, preoperative co-morbidities, intraoperative and postoperative hemodynamic parameters, arterial blood gas analysis (ABG), cardiopulmonary bypass and aortic cross-clamp duration, flow rate, urine output, and blood product and inotropic agent usage, were recorded. Postoperative plasma lactate levels were measured simultaneously with cerebral tissue oxygen saturation (rSO2) in both cerebral hemispheres at 10 different time points.
Interventions
DEVICENear infrared spectroscopy
The rSO2 (cerebral oxygen satutation) was continuously monitored by NIRS (Near infrared spectroscopy) with a sensor positioned on the forehead of the patient
Sponsors
Acibadem University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
43 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* ASA) II-III patients, aged 43-80 years, undergoing on-pump coronary artery bypass grafting
Exclusion criteria
* Active congestive cardiac failure, intraoperative death, urgent cardiac surgery or reoperation, hemodynamic instability or need of inotropic support before the operation, the elevation of any parameters preoperatively suggestive of systemic hypoperfusion, coagulopathy, renal failure, hepatic dysfunction, local or systemic infection, and inflammation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differantial Diagnosis of early hyperlectathemia | through study completion, an average of 1 year | To understand whether early hyperlactathemia after cardiopulmonary bypass surgery is due to hypoxic or non-hypoxic causes, we will look at the correlation between blood lactate level and cerebral oxygen saturation (rSO2) |
Countries
Turkey (Türkiye)
Outcome results
None listed