Dexmedetomidine, Lidocaine, Quality of Recovery(QoR-40), Preoperative and Postoperative
Conditions
Keywords
Lidocaine, Dexmedetomidine, Quality of recovery
Brief summary
BACKGROUND: Some studies have revealed that intravenous (IV) lidocaine or dexmedetomidine might improve the quality of recovery undergoing laparoscopic surgery. The investigators investigated whether co-administration lidocaine and dexmedetomidine could better improve the the quality of recovery after laparoscopic total hysterectomy. METHODS: One hundred and forty-four women with elective laparoscopic total hysterectomy were randomly divided into four groups: Patients in group L received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close the pneumoperitoneum. Patients in group D received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close the pneumoperitoneum. Patients in group LD received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close the pneumoperitoneum, respectively. Patients in group C received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close the pneumoperitoneum. Primary outcome was the quality of recovery (QoR-40) at 1 day prior to sugery, 1 day after sugery, and 2 days after sugery. The secondary outcomes included perioperative remifentanil consumption, postoperative VAS scores, the incidence of postoperative nausea and vomiting, postoperative rescue analgesics and anti-emetics, recovery time, extubation time, and Ramsay sedation scale at 5 min, 10min, 30 min, 60 min after extubation.
Interventions
DRUGCo-administration Lidocaine and Dexmedetomidine
Patients received a bolus infusion of lidocaine (2%; 1.5 mg/kg) and dexmedetomidine (0.5 µg/kg) over 10 min before the induction of anesthesia, and then lidocaine and dexmedetomidine were infused at a rate of 1.5 mg/kg/h and 0.4 µg/kg/h until close of the pneumoperitoneum, respectively.
DRUGDexmedetomidine infusion
Patients received a bolus infusion of dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until close of the pneumoperitoneum.
DRUGLidocaine infusion
Patients received a bolus infusion of lidocaine (2%; 1.5 mg/kg over 10 min before the induction of anesthesia), and then lidocaine was infused at a rate of 1.5 mg/kg/h until close of the pneumoperitoneum.
DRUGSaline infusion
Patients received the same volume of normal saline 10 min before the induction of anesthesia, and then normal saline (0.9%) was continuously infused in an equal volume until close of the pneumoperitoneum.
Sponsors
Anqing Municipal Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* American Society of Anesthesiologists (ASA) physical statusⅠand Ⅱ * Scheduled for elective laparoscopic total hysterectomy
Exclusion criteria
* History of allergy to local anesthetics * BMI\>30 * Severe respiratory disease * Renal or hepatic insufficiency * History of preoperative opioids medication and psychiatric * preoperative bradycardia * preoperative atrioventricular block
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quality of recovery scores(QoR-40) | 1 day after operation | Our primary outcome was Quality of recovery scores(QoR-40) 1 day after operation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Recovery time | Immediately after the surgery | Secondary Outcome Measure was recovery time |
| Extubation time | Immediately after the surgery | Secondary Outcome Measure was extubation time |
| Pain visual analogue scale scores | The first 24 hours after operation | Secondary Outcome Measure was pain visual analogue scale scores |
| Intraoperative remifentanil total dose | Intraoperative | Secondary Outcome Measure was remifentanil total dose during the perioperative period |
| The consumption of sufentanil | The first 24 hours after operation | Secondary Outcome Measure was consumption of sufentanil |
| The length of post-anesthesiacare unit stay | Immediately after the surgery | Secondary Outcome Measure was the length of post-anesthesiacare unit stay |
| PONV scores | The first 24 hours after operation | Secondary Outcome Measure was PONV scores |
Countries
China
Outcome results
None listed