Cataract Senile, Dry Eye
Conditions
Brief summary
First, preoperative biometry of the eye at the IOL Master® will be performed. Then, corneal topography will be measured at the Oculus pentacam®. Afterwards, one of two eye drops are instilled in the eye, and biometry and corneal topography will be repeated after 5 minutes. For all patients, the Barrett Universal II formula will be used for calculation of IOL power. Predicted refraction outcome will be referred to as SEQ. The chief surgeon will perform the uneventful standard cataract operation with in-the-bag implantation of a HOYA IOL (Model 251) through a 2.4-mm corneal incision. A Subjective Refraction using plus principle will be performed one month after the operation, and ETDRS visual acuity charts will be used to measure best-corrected visual acuity. Refraction will be described as SR (postoperative SEQ) and will be calculated as: SR = sphere + (0.5\*cylinder)
Detailed description
First, preoperative biometry of the eye at the IOL Master® will be performed. Then, corneal topography will be measured at the Oculus pentacam®. Patients will be classified as dry eye or normal eye based on BUT. The tear film breakup (BUT) time of less than 5 seconds will be diagnosed as dry eyes.Afterwards, one of two eye drops are instilled in the eye, and biometry and corneal topography will be repeated after 5 minutes. For all patients, the Barrett Universal II formula will be used for calculation of IOL power. Predicted refraction outcome will be referred to as SEQ. The chief surgeon will perform the uneventful standard cataract operation with in-the-bag implantation of a HOYA IOL (Model 251) through a 2.4-mm corneal incision. A Subjective Refraction using plus principle will be performed one month after the operation, and ETDRS visual acuity charts will be used to measure best-corrected visual acuity. Refraction will be described as SR (postoperative SEQ) and will be calculated as: SR = sphere + (0.5\*cylinder)
Interventions
DEVICEsodium hyaluronate 0.1%
Instillation of one drop sodium hyaluronate 0.1%
DEVICEsodium hyaluronate 0.3%
Instillation of one drop sodium hyaluronate 0.3%
Sponsors
Second Affiliated Hospital of Xi'an Jiaotong University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Corneal topography and Biometry will be performed in individuals with age-relate cataract. Patients will be classified as dry eye or normal eye based on BUT. The tear film breakup (BUT) time of less than 5 seconds will be diagnosed as dry eyes. One of two artificial tear eye drops will be instilled in the eye, and corneal topography and biometry will be repeated after 5 minutes of application
Eligibility
Sex/Gender
ALL
Age
30 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* A patient diagnosed with age related cataract * 30 to 95 years old * Medical history and physical examination should be normal.
Exclusion criteria
* • Abnormality of the cornea (scaring of the cornea) * If any topical therapy (i.e. glaucoma) of the eye is needed * Active allergy of eye or nose * Any conjunctivitis or keratitis * If nasolacrimal drainage apparatus is abnormal * severity level 4 of dry eye (constant discomfort in the eye accompanied with visual symptoms, filamentary keratitis, , keratinization, severe conjunctival injection, ulceration clumping of mucus glands, tear debris, , trichiasis, symblepharon) * deformities of lid * Preceding eye trauma or surgery * Any Uncontrolled ocular disease or systemic disease * Lactation * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| keratometric value of the eye measured with Master 500 before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | k-value (k, k1, k2 in Diopter) |
| Axial length of the eye measured with Master 500 before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | Axial length (AL in mm) |
| Anterior chamber depth of the eye measured with Master 500 before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | Anterior chamber depth (ACD in mm) |
| Sim K of the eye measured with Oculus Pentacam before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | Sim K (k1, k2 in Diopter) |
| Total Corneal Refractive Power of the eye measured with Oculus Pentacam before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | Total Corneal Refractive Power (TCRP in Diopter), |
| Total Corneal Irregular Astigmatism of the eye measured with Oculus Pentacam before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | Total Corneal Irregular Astigmatism (TCIA in Diopter) |
| Predicted spherical equivalent (SE) calculated with Barrett Universal II formula before and after 5 minutes of installation of artificial tears (sodium hyaluronate 0.1% or 0.3% eye drops). | 5 minutes | Predicted spherical equivalent (SEQ in Diopter) |
| Postoperative spherical equivalent (SE) measured one month after surgery. | one month after surgery | Postoperative spherical equivalent (SE in Diopters) |
Countries
China
Contacts
Primary ContactLing Bai, MD,PhD
Outcome results
None listed