Study the Role of SHMT1 Polymorphism in Parkinson Disease
Conditions
Keywords
SHMT1 polymorphism, Parkinson disease
Brief summary
Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.
Detailed description
This case -control observational prospective study will conducted on 40 patients with PD.
Interventions
GENETICSHMT1 polymorphism
It is to identify the role of SHMT1polymorphism in PD and examine the relationship between it and Severity of PD.
Sponsors
Aswan University Hospital
Assiut University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients age ≥ 50 years. * Patients with PD diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UK PDS Brain Bank diagnostic criteria)
Exclusion criteria
* Patients with parkinsonian plus syndrome * Patients with secondary parkinsonism * Patients with other chronic comorbidities (renal, hepatic, and endocrinal disturbances and chronic chest disease.) * Past and /or present history of epilepsy. * Patients with disturbed conscious level.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| polymorphism of SHMT1gene | one year |
Secondary
| Measure | Time frame |
|---|---|
| the role of SHMT1plymorphism in pathogenesis PD | one year |
| Study the relationship of Shmt1 polymorphism to the severity of Parkinson disease | One year |
Countries
Egypt
Contacts
Primary ContactEffat a Tony, MD
Backup Contactabeer a tony, MD
Outcome results
None listed