Gynecologic Cancer
Conditions
Keywords
3D Ultrasound, Intervention
Brief summary
Brachytherapy treatment in gynecological cancers is an essential component to delivering adequate doses of radiation to a tumour while sparing normal tissue. Interstitial or intra-cavitary brachytherapy are often needed in advanced or recurrent disease, in cases where intrauterine brachytherapy may not deliver the optimal outcome. Interstitial or intra-cavitary brachytherapy are based on a defined template-and-needle system, and the procedure relies on clinical examination and pre-treatment imaging to guide needle insertion. There is currently no standard image-guided process to help direct needles in the pelvis. We propose using 3D ultrasound to provide real-time imaging for the brachytherapy procedure, which will aid in avoiding needle insertion into pelvic organs and result in optimal dose coverage to the tumour.
Interventions
DEVICEGynecological brachytherapy
Management of gynecological malignancies is done through brachytherapy treatment, which involves the delivery of radiation via radioactive sources that are placed into or in close proximity to the tumour.
Sponsors
Western University, Canada
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Patients who are assigned to gynecological brachytherapy
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Females of age eighteen (18) or greater. * Patients with locally advanced or recurrent gynecological malignancies who are offered interstitial or ring and tandem brachytherapy treatment. These typically would include patients with primary or recurrent vaginal cancers, endometrial cancers or cervical cancers. Histologies of these cancers are typically adenocarcinomas or squamous cell carcinomas
Exclusion criteria
• Above patients who are not offered interstitial brachytherapy as a treatment modality
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Needle Localization Accuracy | 16 Months | Observed needle locations in 3-D TVUS and CT planning images are measured and compared. |
Countries
Canada
Contacts
Primary ContactDavid D'Souza, MD
Outcome results
None listed