Brain Cancer, Prostate Cancer
Conditions
Brief summary
In radiotherapy, Magnetic Resonance Imaging (MRI) is used as a complement to the CT scanner because it provides better tissue contrast and therefore more precise delineations without the need for additional irradiation. However, MRI does not allow the definition of the electronic densities of the tissues necessary for dose calculation. In this work, we sought to measure the feasibility of a method for generating CT-synthetic images from MRI in terms of dosimetric and geometrical precision for the purpose of MRI workflow alone (see diagram). The cerebral sphere and the prostate are the two tumor locations considered. All patients will have a planning CT (reference) and an MRI in the treatment position. The contours of the structures will be contoured by a radiotherapist on both the MRI and the reference CT. Synthetic CTs will be generated from the MRI with the method of automatic assignment of densities in five classes. The volumes bypassed and the dosimetries performed will be compared. A study of the quality of the images generated from MRI for dose calculation and images for the verification of per-treatment positioning will be performed.
Detailed description
This is a prospective single-center dosimetry study that exhaustively included brain tumor and prostate cancer patients treated at the ICO Site d'Angers by external radiotherapy and prior to which they were given an MRI and a simulation CT in treatment position over a 12-month period. For patients who agree to participate in the study, CT-synthetic images will be generated from the MRI images by automatic assignment of densities (5 classes). Reference CT images from CT and synthetic CT images from MRI will be available for comparison for all eligible patients.
Interventions
DIAGNOSTIC_TESTSynthetic CT Scan
method of generating CT-synthetic image from MRI
Sponsors
Institut Cancerologie de l'Ouest
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years old 2. Male or Female with a (primary) brain tumour or Male with cancer and localized (non-metastatic) prostate cancer 3. Patient having benefited from a planning MRI scan in treatment position performed according to the new acquisition modalities (allowing the generation of CT-synthetics by automatic assignment of densities) performed since January 2020 and a planning scanner in treatment position prior to external radiotherapy. 4. Good general condition (SP \< 3)
Exclusion criteria
1. Excluded forms of the disease, 2. MRI-specific contraindications (claustrophobia, foreign bodies) 3. Obesity preventing the placement of equipment (contention/antennae) 4. Poor general condition (SP \> or = 2) preventing the patient from standing on the table -
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| describe the differences in volumetric and dosimetric accuracy between potential planning from MRI alone by CT-synthetics generation and standard planning from CT | 3 month | Comparison of the contours of target volumes and organs at risk and comparison of dose distributions (dosimetries) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of the quality of images generated from MRI for dose calculation and images for verification of per-treatment positioning relative to the reference CT in an MRI-only workflow objective. | 3 month | Comparison of CT-synthetic CT images generated from MRI to the reference CT and Comparison of shifts performed during patient repositioning |
Countries
France
Outcome results
None listed