Sleep Apnea
Conditions
Keywords
Sleep apnea, Follow-up, Cardiovascular event, Metabolic event, incident cancer, Death
Brief summary
The meta-analysis sleep apnea syndrome and arterial stiffness includes data from 893 patients initially included in 9 studies conducted by the EFCR Department of the CHUGA between 2006 and 2015, presenting a sleep apnea syndrome (SAS) with exploration of their arterial stiffness via the measurement of pulse wave velocity (PWV). Currently, we do not have long-term follow-up data for these patients. The first objective of the PWV Follow-up project is to collect cardiovascular events in these patients through telephone interviews and a structured questionnaire to determine the prevalence of these events. The prevalence of metabolic events, incident cancers and deaths will be also determined as secondary objectives through the same questionnaire. Others secondary objectives are to evaluate the impact of continuous positive airway pressure (CPAP, the reference treatment for OSA) on the occurrence of cardiovascular and metabolic events and incident cancers, as this is still discussed in the literature.
Detailed description
The meta-analysis sleep apnea syndrome and arterial stiffness includes data from 893 patients initially included in 9 studies conducted by the EFCR Department of the CHUGA between 2006 and 2015, presenting a sleep apnea syndrome (SAS) with exploration of their arterial stiffness via the measurement of pulse wave velocity (PWV). The 9 studies were referred as : ADISAS (NCT011968), AGIRSASADOM (NCT010902), BPCO (NCT004044), BPCO-SAS (NCT01195064), DIAMETASAS, Aortic Dissection (NCT01068691), INFRASAS (NCT010892), VALSAS (NCT004094), NIV-OHS (NCT006030). The objective of this meta-analysis on individual data was to understand the relationship between the severity of the sleep apnea syndrome (measured by the apnea + hypopnea index) and arterial rigidity at the time of diagnosis of SAS. Currently, we do not have long-term follow-up data for these patients. The first objective of the PWV Follow-up project is to collect cardiovascular events in these patients through telephone interviews and a structured questionnaire to determine the prevalence of these events. The prevalence of metabolic events, incident cancers and deaths will be also determined as secondary objectives through the same questionnaire. Others secondary objectives are to evaluate the impact of continuous positive airway pressure (CPAP, the reference treatment for OSA) on the occurrence of cardiovascular and metabolic events and incident cancers, as this is still discussed in the literature.
Interventions
OTHERQuestionnaire
Structured questionnaire to collect cardiovascular and metabolic events, incident cancers and deaths that have occured, as weel as information on CPAP, through telephone interview.
Sponsors
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* already included in the meta-analysis sleep apnea syndrome and arterial stiffness.
Exclusion criteria
* refusal to participate * family not reachable and death not identified in the Hospital medical base * persons under judicial protection (article L1122-2 of the Public Health Code) and patients under guardianship or curatorship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of cardiovascular events | up to 15 years | Prevalence of cardiovascular events during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of incident cancers | up to 15 years | Prevalence of incident cancers during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire.. |
| Prevalence of deaths | up to 15 years | Prevalence of deaths during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire. |
| Prevalence of metabolic events | up to 15 years | Prevalence of metabolic events during the follow-up of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness, through a structured questionnaire. |
| Effect of CPAP treatment on the metabolic events occurrence | during 6 months | Mean CPAP observance (h/night) of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness to determine its impact on the metabolic events occurrence. |
| Effect of CPAP treatment on the incident cancers occurrence | during 6 months | Mean CPAP observance (h/night) of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness to determine its impact on the incident cancers occurrence. |
| Effect of CPAP treatment on the cardiovascular events occurrence | during 6 months | Mean CPAP observance (h/night) of patients included in the meta-analysis sleep apnea syndrome and arterial stiffness to determine its impact on the cardiovascular events occurrence. |
Countries
France
Outcome results
None listed