Cannabis
Conditions
Brief summary
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Detailed description
To characterize the acute effects of vaporized THC in women relative to men and to begin probing the mechanisms that may underlie gender differences.
Interventions
DRUGInhaled THC
4 mg inhaled THC
DRUGPlacebo
Inhaled placebo (no active cannabinoids)
Sponsors
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* At least one lifetime exposure to cannabis * Good physical and mental health
Exclusion criteria
* Cannabis naïve individuals * Major current or recent stressors
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline: Rewarding Effects measured by Visual Analog Scale (VAS) | Changes in "high" assessed over the following timepoints: baseline, +60, +80, +120, +180, +300 minutes after start of oral Dronabinol administration. | Subjective measure of THC induced "high" |
| Change from Baseline: Verbal Learning: Measured by Rey Auditory Verbal Learning Test (RAVLT) | Baseline and +80 minutes after start of oral Dronabinol administration. | Measured as delay recall on the AVLT |
Countries
United States
Contacts
CONTACTCarly Hewes, BS
Outcome results
None listed