Non Small Cell Lung Cancer
Conditions
Brief summary
The basic premise of this pilot study is to enroll 40 patients over 3 years who have Stage II, III, or IV non-small cell lung cancer and are planned for definitive treatment with concurrent chemoradiation where a contrast enhanced 4DCT is planned.
Interventions
PROCEDUREcontrast enhanced 4DCT
Functional Lung Imaging with DECT and 4DCT
Sponsors
Abramson Cancer Center at Penn Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients have histologic diagnosis of non-small cell lung cancer * Patients have AJCC stage II, III or IV disease were the plan is to receive definitive concurrent chemoradiation to 60 Gy or higher * Age \> 18 years of age * Patients are able to provide informed consent * No additional lung radiation is planned until after the 2nd CT on this study (i.e. patient does not have a solitary pulmonary nodule or second primary that the plan is to undergo SBRT) * Patient must have adequate kidney function to receive IV contrast (following institutional policy supplied by radiology). The cutoff level for serum creatinine is 1.6 mg/dL * Negative urine pregnancy test before every CT scan
Exclusion criteria
* Allergy to IV iodine contrast * Severe claustrophobia * Further thoracic radiation therapy is planned.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| evaluate the reproducibility of PBV DECT imaging and 4DCT derived lung ventilation for evaluating lung function | 3 years |
| correlate changes of PBV DECT and 4DCT lung function images seen at ~6 months with radiation dose and with patient reported outcome quality of life | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| • To propose a novel biologic (i.e. functional) dose volume algorithm to reduce PBV and 4DCT lung function changes | 3 years |
Countries
United States
Outcome results
None listed