Ketamine Adverse Reaction, Pain, Acute, Pain, Intractable, Pain, Postoperative, Pain, Refractory
Conditions
Keywords
pain score reduction, reduction in pain scores, post-operative pain, ketamine use in recovery room, recovery room, ketamine recovery, ketamine rescue
Brief summary
Observational study to assess efficacy of IV ketamine bolus when used in the post anesthesia recovery unit for uncontrolled pain despite use of opioids.
Detailed description
In this observational study, the investigators will monitor all patients with significant pain after any non-cardiac surgical intervention at the University of Alberta Hospital. After receiving an adequate dose of potent opioids (hydromorphone, morphine), the participants will receive up to 0,2-0,25 mg/kg IV ketamine bolus. In our center these boluses are given with 10-20mg increments. The adequate dose of opioids will be determined by the attending anesthesiologist, depending on what patients received intraoperatively and on their comorbidities. Pain scores will be assessed before and after administration of this drug. The incidence of any side effect after ketamine administration will be documented.
Interventions
DRUGKetamine
IV ketamine - 10mg bolus may be repeated repeated 2-3 times depending on clinical judgement
Sponsors
University of Alberta
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Adult patients undergoing non cardiac surgery at University of Alberta Hospital meeting the following criteria: * age ≥ 18 * significant pain despite narcotics used in post-anesthesia care unit * ketamine ordered by attending anesthesiologist
Exclusion criteria
* Patient refusal to receive ketamine * Patients undergoing cardiac surgery * Patients who received no narcotics * Contra-indication to receiving ketamine (determined by attending anesthesiologist)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduction in pain score after ketamine use in PACU | in the immediate post-operative period in recovery room | The Numeric Rating Scale (NRS-11) is an 11-point scale for patient self-reporting of pain. It is what is used most often in our recovery room for pain assessment. A score of 0/10 means no pain, and 10/10 means worst pain. |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of side effects after ketamine use | in the immediate post-operative period in recovery room |
Countries
Canada
Outcome results
None listed