Chronic Renal Failure, Urinary Extracellular Vesicle
Conditions
Keywords
urinary extracellular vesicle, Chronic Renal Failure
Brief summary
The recent discovery of extracellular vesicles (EV) as a mechanism of intercellular communication has made it possible to develop a new field of health research and could bring new information on the pathological mechanisms of renal diseases. Definition of physiologic and pathologic values of urinary extracellular vesicles (EVu) between healthy subjects and chronic kidney diseases (CKD) patients could be a new tool for follow up of renal diseases. EV are found in all biological fluids including urine, that's why they are increasingly analyzed in renal pathologies. The main objective of this study is to determine the physiological values and the pathological thresholds of EVu.
Interventions
DIAGNOSTIC_TESTurinary extracellular vesicle concentration
urinary extracellular vesicle concentration will be determined in urine samples from CRF and healthy patients
DIAGNOSTIC_TESTblood sample
blood sample in order to determine creatin level
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subject \> 18 years old * healthy subjects : no medical history, in particular cardiovascular, without drug treatment, without proteinuria, normal BMI * CRF patients : eGFR estimated according to the MRDR formula less than 89 mL/min/1,73m²
Exclusion criteria
* patients under dialysis protocols * renal transplant patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| variation of urinary extracellular vesicle concentration between both groups | one day | variation of urinary extracellular vesicle concentration between both groups : healthy and CRF patients Urinary extracellular vesicle concentrations will be measured as number of extracellular vesicles per mL of urine |
Countries
France
Outcome results
None listed