Hospital-acquired Pneumonia, Ventilator-associated Pneumonia
Conditions
Brief summary
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP.
Detailed description
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP. Patients with respiratory culture data signifying a Gram-negative organism as the cause of HAP/VAP will be analyzed as described below if study inclusion criteria is met. Minimum inhibitory concentration (MIC) data will interpreted per Clinical & Laboratory Standards Institute (CLSI) standards to determine local patterns of resistance. Multivariable logistic regression will be performed to determine risk factors for piperacillin-tazobactam, cefepime or meropenem resistant Gram-negative isolates. Project target date of completion and close-out is May 2021.
Interventions
OTHERObservational
Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP
Sponsors
Methodist Health System
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* ICU, Neuro critical care unit admission * Diagnosis of HAP or VAP * Respiratory culture positive for Gram-negative organism
Exclusion criteria
* ICU length of stay \<48 hours prior to HAP/VAP * Culture or MIC data unavailable * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of Gram-negative isolate resistance to piperacillin-tazobactam, cefepime, meropenem | April 2017 - May 2020 | Percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of susceptibility to non-beta lactam antipseudomonal agents | April 2017 - May 2020 | Percentage |
| in-hospital mortality | April 2017 - May 2020 | Percentage |
| need for mechanical ventilation | April 2017 - May 2020 | Percentage |
| duration of mechanical ventilation | April 2017 - May 2020 | number of days |
| development of septic shock | April 2017 - May 2020 | Percentage |
| ICU length of stay | April 2017 - May 2020 | number of days |
| hospital length of stay | April 2017 - May 2020 | number of days |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMatthew Crotty, PharmD
Methodist Health System
Outcome results
None listed