The Effects of n-3 LCPUFAs in Patients With Colorectal Cancer

Single-blinded, Randomized, Controlled Trial About the Effects of n-3 LCPUFAs on Weight and Functional Status in Patients With Colorectal Cancer.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04699760

Enrollment

Registered

2021-01-07

Start date

2015-04-30

Completion date

2015-09-30

Last updated

2021-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Cachexia, Quality of Life, Side Effects

Keywords

cancer, nutrition, fish oil

Brief summary

The aim of this study is to determine the effects of n-3 PUFAs on weight, physical funktion and quality of life in patients with colorectal cancer.

Detailed description

Primary outcomes: * Weight * Physical function * Hand-grip strength Secondary outcomes: * Quality of life * Mid-upperarm circumference * Incorporation of n-3 PUFAs into cell membranes

Interventions

DIETARY_SUPPLEMENTFish Oil

8 weeks, 2.2 G EPA/day

DIETARY_SUPPLEMENTPlacebo

Placebo

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* ≥18 years * Patients with diagnosed colorectal cancer with metastases treated with chemotherapy on Rigshospitalet, Copenhagen

Exclusion criteria

* \< 18 years * Patients in palliative care * patients with haemophilia * Patiens in treatment of anti-coagulation * Patients with genetic hyperkolesterolemia * Pre-dialytic patients (GFR\<15ml/min/1,73m2 eller kreatinin ≥500 mmol/L)

Design outcomes

Primary

Measure	Time frame	Description
Weight loss	8 weeks	Difference in weight (kg) from inclusion to 8 week status

Secondary

Measure	Time frame	Description
quality of Life score	8 weeks	score - difference from inclusion to 8 week status (EORTC QLQ-C30 questionnaire)
Performance status - common daily abilities	8 weeks	combined scale - score - ADL

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026