Parkinson Disease
Conditions
Keywords
transcranial magnetic stimulation, dexterity, video game-based training
Brief summary
We investigate the effectiveness of a combined repetitive transcranial magnetic stimulation (rTMS) - video game-based training (VBT) dexterity intervention in Parkinson's diseases. The short and long-term benefits of this training program will be evaluated. For these purposes, a blinded sham controlled randomized controlled trial will be performed.
Detailed description
Patients with Parkinson's disease (PD) often exhibit dexterous difficulties during the performance of activities of daily living (ADL) such as tying shoe laces, hand-writing, using remote controls, smartphone or tablet. These difficulties further add to the burden of the disease, leading to reduced quality of life (QoL). A relatively new, but rapidly growing aspect of training in PD neurorehabilitation is exergaming. To enhance training effects a combination of repetitive transcranial magnetic stimulation (rTMS) with exergaming will be tested.
Interventions
OTHERTranscranial magnetic stimulation
Non-invasive brain stimulation
OTHERSham transcranial magnetic stimulation
Non-invasive brain stimulation
Sponsors
Luzerner Kantonsspital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Masking description
rTMS protocol either sham or real
Intervention model description
blinded randomised clinical trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Confirmed PD 2. Hoehn & Yahr I to IV 3. Age 50-80 years old 4. written and signed informed consent 5. dexterous difficulties-
Exclusion criteria
1. Significant medical, psychiatric co-morbidity including dementia as defined by Montreal Cognitive Assessment (MOCA \< 21) 2. Inability to understand the scope of the study and to follow study procedures according to the protocol e.g. complete questionnaires (i.e. due to cognitive problems) 3.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| DextQ-24 | 3 weeks | standardized patient self-rated outcome measure (PROM) for evaluating dexterity related ADL in PD |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Nine Hole Peg test (9-HPT) | 3 weeks | The 9-HPT is a standardized, well established, and reliable measure of hand dexterity in patients with PD. |
| Coin rotation task (CRT) | 3 weeks | The CRT measures fine coordinated finger movements and is a suitable and valid dexterity test in patients with PD. |
Countries
Switzerland
Outcome results
None listed