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Immune and Scfa Profile of Stunting Children

Differences in Immune Status and Fecal SCFA Between Indonesian Stunted Children and Children With Normal Nutritional Status

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04698759
Enrollment
131
Registered
2021-01-07
Start date
2020-01-09
Completion date
2020-11-11
Last updated
2021-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatty Acid, Immune Deficiency, Stunting

Keywords

immune status, stunting, Normal Nutritional Status, Indonesian Children, Gut Microbiota, SCFA

Brief summary

1. Type and Research Design A cross-sectional study design with a quantitative approach will be conducted. Cross-sectional research design is one-time research to find a relationship between the independent variable (risk factor) and the dependent variable (effect). 2. Time and Location of Research The research will be conducted for approximately six months in 2020 at Banten Regency (namely Tegal Ongok and Pasirkarang) and Sumedang Regency. 3. Population and Research Sample The population is children between three and five years old in the village of stunting locus. The sampling method to be used in this research was quota sampling, namely 50 stunting and 50 healthy children from each Regency.

Detailed description

The variables studied will be the nutritional status of children between three and five years old, the characteristics of these children (age, sex, LBW, birth length, history of immunization, history of diarrhea, history of upper respiratory tract infection, food intake), mother and family characteristics (mother's age, mother's education, mother's occupation, father's occupation), home environment (aspects of the components of the house, aspects of sanitation facilities, aspects of occupant behavior), the composition of the intestinal microbiota. Data will be obtained through measurements, interviews using a questionnaire, and direct observation using a checklist. Stunting anthropometric measurements are measured based on parameters of length/height according to age compared to the WHO anthropometric standards 2005 and the Indonesian Minister of Health Decree No. 1995 / MENKES / SK / XII / 2010. The nutritional status of each child included in this study will be quantified using the WHO recommended three nutritional Z-scores namely, height for age (referred to in this study as Zscore 1. weight for age (referred as Z-score 2. and weight for height (referred as Z-score 3. .A structured questionnaire was used for face-to-face interviews with the respective child mother to collect sociodemographic information. In addition, age and anthropometric measurements (height, weight) based on the Department of Health Ministry of Indonesia The regulation will be recorded. For stunting, the thresholds for height-for-age are: 'severely stunted' (\<-3 SD); 'stunted' (-3 SD to \< -2 SD); 'normal' (-2 SD to +3 SD); 'tall' (\> +3 SD). Furthermore, in order to obtain an overall measure of the nutritional status of these children, the children will be classified into weight-for-height categories: 'severely wasted' (\<-3 SD); 'wasted' (-3 SD to \< -2 SD); 'normal' (-2 SD to +1 SD); 'possible risk of overweight' (+1 SD to +2 SD); 'overweight' (\> +2 SD to +3 SD); 'obese' (\> +3 SD)

Interventions

OTHERNo Intervention

no Intervention

Sponsors

Yayasan Rumah Sakit Islam (YARSI) University
CollaboratorUNKNOWN
Universitas Kristen Indonesia
CollaboratorOTHER
Maastricht University
CollaboratorOTHER
Bina Nusantara University
Lead SponsorOTHER

Study design

Observational model
ECOLOGIC_OR_COMMUNITY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
3 Years to 5 Years
Healthy volunteers
Yes

Inclusion criteria

* Children age : 3 - 5 years old (36-60 months) * Live in the research area * Apparently healthy children, after examination by a physician * Involved in a research study (informed consent signed by parent or guardian)

Exclusion criteria

* Children age \< 36 month and \> 60 month * Live outside research area * Unhealthy, after examination by a physician

Design outcomes

Primary

MeasureTime frameDescription
sIgA1 week analysisUnit : ul/ml from feses extract
TNF alfa1 week analysisunit pg/mL from serum
LBP1 week analysisUnit ul/ml from serum
TGF beta1 week analysisUnit : pg/mL from serum
IL -101 week analysisunit pg/ml from serum

Secondary

MeasureTime frameDescription
Short Chain Fatty Acid1 monthsAcetate, Propionate, Butyrate, Isobutyric, Isopropionic , unit mM

Other

MeasureTime frameDescription
Microbiota profile2 monthsrelative abundance microbiota profile

Countries

Indonesia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026