Neurocognitive Disorders
Conditions
Brief summary
Perioperative neurocognitive disorders(PND) is common to see in elderly patients. Although PND increases patient mortality as well as hospitalization time, apparent inflammatory factors, and related mechanisms are still unknown. Metabolites could reveal chemical fingerprints left behind by cellular processes, which in turn provide a new aspect to understand the biological process behind. we aim to found the metabolomics can aid the development of diagnostic markers of PND screening, early detection, and further, provide a basis for disease prevention and treatment.
Interventions
None listed
Sponsors
wenbinlu
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Parkinson's patients undergoing elective deep brain stimulation * Age ≥55 years * ASA physical statusⅠ-Ⅲ * Elementary school or above
Exclusion criteria
* patients with ASA physical status\>III * patients with systemic immune diseases, hematological diseases (hematological tumors or leukemia), patients after transplantation, malignant tumors * patients with metabolic diseases such as diabetes, ketoacidosis, hyperosmolar syndrome, long-term hypoglycemia,gout * patients who refused to join the study and lost to follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the level of metabolomics in patients' blood sample | baseline |
Secondary
| Measure | Time frame |
|---|---|
| CAM-ICU score | baseline |
Countries
China
Contacts
Primary Contactwenbin lu
Backup Contactjinjun bian, M.D
Outcome results
None listed