Sickle Cell Disease, Vitamin D Deficiency
Conditions
Keywords
Vitamin D deficiency prevalence rate, Vitamin D level, Children with sickle cell disease
Brief summary
Vitamin D deficiency may be under-diagnosed in sickle cell disease French children. Therefore, the investigator need an epidemiologic study about the prevalence of vitamin D deficiency in this specific population. There are not specific guidelines neither testing nor treatment. The investigator propose to test vitamin D status in all children with sickle cell disease who are consulting their referring haematologist doctor or in the emergency ward.
Interventions
BIOLOGICAL25-OH Vitamin D measure
As a complement to the off-study prescription, the investigator are taking two 1 mL tubes of extra blood to measure vitamin D, calcium, phosphorus, parathyroid hormone (PTH) and creatinine.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 17 Years
Healthy volunteers
No
Inclusion criteria
* Children: under 18 years old * Sickle cell any genetic type homozygous or composite heterozygous * To receive an assessment independently of the study, during a presentation to the emergency ward and/or a follow-up consultation by the hematologist * no parental opposition signed by at least one parent/legal representative and no child opposition * social security beneficiary
Exclusion criteria
* History of hematologic grafting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of 25-OH Vitamin D level | Day 1 | We classify vitamin D status as follows : * Sufficiency \> \>75nmol/L (\>30 ng/mL) * Insufficiency 50-75 nmol/L (20-30 ng/mL) * Deficiency 12-50nmol/L (5-20 ng/mL) * Severe deficiency \<12 nmol/L (\<5 ng/mL) |
Countries
France
Outcome results
None listed