Relationship Between Strain and Stroke Volume in Cardiac Surgery

Relationship Between Right Ventricular Free Wall Longitudinal Strain and Stroke Volume Index by Thermodilution in Patients Undergoing Cardiac Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04694378

Enrollment

Registered

2021-01-05

Start date

2020-10-01

Completion date

2022-11-01

Last updated

2024-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Longitudinal Heart Strain, Right Ventricular Dysfunction, Stroke Volume Index

Keywords

Echocardiography, Coronary artery bypass graft, Thermodilution

Brief summary

Patients undergoing coronary artery bypass grafting up tp 30% will develop postoperative right ventricle dysfunction. Its imperative for the physician to fully understand the severity of this complication in order to perform an early diagnosis and carry out the appropriate treatment. Aim: Investigate the correlation between echocardiographic measurements and hemodynamic changes at different time points in patients undergoing coronary artery bypass graft surgery Hypothesis: 1. Weak correlation between echocardiographic measurements and hemodynamic changes during coronary artery bypass graft surgery 2. Echocardiographic measurements would change across different time points during surgery independent of hemodynamic values.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

\- Elective coronary artery bypass graft patients who require pulmonary catheter placement for intraoperative monitoring.

Exclusion criteria

* Patients with contraindication to Swan-Ganz catheter placement, * Pre-existing atrial arrhythmias, * Patients with moderate and/or severe mitral/tricuspid valve stenosis or regurgitation * Patients with contraindication to transesophageal echocardiogram probe placement (i.e. esophageal stenosis).

Design outcomes

Primary

Measure	Time frame	Description
Change of right ventricular function during CABG assessed by right heart strain (%)	during CABG surgery	Assessing the change of RV function during CABG surgery using right heart strain as a percentage of change between RV shortening and RV end diastolic length.
Change of right ventricular function during CABG assessed by stroke volume index (mL/m2)	during CABG surgery	Assessing the change of RV function during CABG surgery using stroke volume index. Stroke volume index measurement as millilitres per square meter (ml/m2)

Secondary

Measure	Time frame	Description
Change in cardiac output measured with Swan-Ganz during CABG	during CABG surgery	Cardiac output (L/min) measured with the thermodilution technique

Countries

United States

Outcome results