Colorectal Cancer
Conditions
Brief summary
Immunonutrition (IN) appears to reduce infective complications and in-hospital length of stay (LOS) after gastrointestinal surgery. More specifically, it seems to be beneficial also in colorectal cancer surgery. Potential benefits of combining preoperative IN (PIN) with protocols of enhanced recovery after surgery (ERAS) in reducing LOS in laparoscopic surgery are yet to be determined.
Interventions
DIETARY_SUPPLEMENTImmunonutrition
nutridrinks 3 times a day 5 days prior surgery plus maltodextrins the day of surgery
Sponsors
University of Rome Tor Vergata
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* laparoscopic colorectal resection for cancer following ERAS protocol * \>18 years old * elective setting
Exclusion criteria
* age below 18 * malnutrition * inflammatory bowel disease * acquired or congenital immunodeficiency * preoperative infection * ASA IV * pregnancy * emergency setting * conversion to open surgery * multivisceral resections
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay | up to 30 days after discharge | number of days between primary colorectal resection and discharge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to first defecation | up to 30 days after discharge | number of days between primary colorectal resection and first defecation |
| 30-days postoperative complications | up to 30 days after discharge | Rate of any complication after colorectal resection |
| Surgical site infection | up to 30 days after discharge | rate of any surgical site infection clinically demonstrated |
| Anastomotic leak | up to 30 days after discharge | rate of any postoperative leakage of colo-rectal, colo-colic or ileo-colic anastomosis, clinically, radiologically or endoscopically demonstrated |
| Time to postoperative food intake | up to 30 days after discharge | number of days between primary colorectal resection and refeeding |
| 30-days Mortality | up to 30 days after discharge | Rate of any mortality |
| Pneumonia | up to 30 days after discharge | rate of radiologically demonstrated pneumonia |
| Ileus | up to 30 days after discharge | rate of any ileus clinically demonstrated |
| Prolonged length of stay | up to 30 days after discharge | rate of any patient discharged after 8 days |
| Readmission | up to 90 days after discharge | Rate of any unplanned readmission after discharge |
Outcome results
None listed