Effect of Abdominal Wall Activity on the Responses to Meal Ingestion

Factors That Determine the Responses to Meal Ingestion: Effect of Abdominal Wall Activity

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04691882

Enrollment

Registered

2020-12-31

Start date

2020-10-12

Completion date

2021-01-22

Last updated

2021-02-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

meal ingestion, postprandial responses, hedonic sensations, homeostatic sensations, abdominal wall activity, abdominal distension

Brief summary

Meal ingestion induces sensations that are influenced by a series of conditioning factors. Aim: to determine the effect of abdominal wall activity on the responses to a standard probe meal. Study in healthy subjects comparing postprandial digestive sensations (abdominal bloating and digestive well-being) during consecutive maneuvers of diaphragmatic contraction (i.e. descent) versus diaphragmatic relaxation (i.e. ascent) in a cross-over randomized design. Primary outcome: effect of somatic maneuvers on abdominal bloating sensation; secondary aim: effect on digestive well-being. Participants (16 women) will be instructed to eat a standard dinner the day before, to consume a standard breakfast at home after overnight fast, and to report to the laboratory, where the test meal will be administered 4 h after breakfast. Studies will be conducted in a quiet, isolated room. Participants will be taught to produce diaphragmatic contraction and visible abdominal distention. A probe meal up to maximal satiation will be administered to induce abdominal fullness/bloating sensation; immediately after ingestion, bloating sensation (from 0 to 10) and digestive well-being (from -5 to +5) will be scored during 8 alternating episodes (30 s each) in random sequence of diaphragmatic contraction (abdominal distension) versus diaphragmatic relaxation.

Interventions

BEHAVIORALDiaphragmatic contraction

Sequential periods (30 s) of voluntary diaphragmatic contraction after meal ingestion

BEHAVIORALDiaphagmatic relaxation

Sequential periods (30 s) of voluntary diaphragmatic relaxation after meal ingestion

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* non-obese

Exclusion criteria

* history of gastrointestinal symptoms * prior obesity * use of medications * history of anosmia and ageusia * current dieting * alcohol abuse * psychological disorders * eating disorders

Design outcomes

Primary

Measure	Time frame	Description
Changes in abdominal fullness/bloating sensation induced by the probe meal	10 min	Effect of abdominal wall activity on abdominal fullness/bloating \[measured by 10 cm scale graded from 0 (not at all) to 10 (very much)\]

Secondary

Measure	Time frame	Description
Changes in digestive well-being sensation induced by the probe meal	10 min	Effect of abdominal wall activity on digestive well-being \[measured by 10 cm scale graded from -5 (extremely unpleasant sensation) to +5 (extremely unpleasant extremely pleasant sensation)\]

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 16, 2026