Substance Use Disorders
Conditions
Brief summary
Repetitive Trans-cranial Magnetic Stimulation (rTMS) is a relatively safe and non-invasive method to modulate neuronal activity; rTMS uses alternating magnetic fields in a certain frequency to induce an electric current in the underlying brain tissue. Administering high frequency rTMS to the left dorsolateral prefrontal cortex is possible to increase brain activity in the stimulated area and to change brain activity in associated regions that are part of the same neural circuit which may reduce craving.
Interventions
Repetitive Trans-cranial Magnetic Stimulation (rTMS) is a relatively safe and non-invasive method to modulate neuronal activity; rTMS uses alternating magnetic fields in a certain frequency to induce an electric current in the underlying brain tissue.
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Masking description
single blind sham-controlled randomized clinical trial
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
1. Age range: 18-45 years old 2. Gender: males 3. Opioid Use disorder according to the DSM-5 (early abstinence starting 1 week up to 1 month).
Exclusion criteria
1. Presence of other serious mental illness (e.g.; psychotic disorders, bipolar affective disorder, depression with psychotic features). 2. Patients with any other serious medical illness. 3. Previous treatment with repetitive Trans- cranial magnetic stimulation. 4. Patients with contraindications to rTMS as cardiac patient with pacemaker.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| craving severity | 6 weeks | measure severity of drug craving using craving severity scale, the scale is called brief substance craving scale. a higher outcome is a worse result |
| heroin craving | 6 weeks | using the heroin craving questionnaire, a higher score indicates a worse outcome |
Contacts
Primary ContactNoha Ahmed saad, bch,MS
Outcome results
None listed