Cerebral Hemodynamics and Oxygenation in Critically Ill Patients

Cerebal Hemodynamics and Oxygenation in Critically Ill Patients : Characterization and Effects of Therapeutics

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04690530

Enrollment

Registered

2020-12-30

Start date

2026-03-01

Completion date

2027-03-01

Last updated

2026-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Brief summary

Critically-ill patients frequently experience marked changes in mean arterial pressure and carbon dioxide partial arterial pressure, the two major determinants of the cerebral blood flow. In addition, many therapeutics (fluids, vasopressors or inotropes administration, blood transfusion, prone positioning...) can influence these two determinants of cerebral blood flow and thus cerebral blood flow, especially in patients with altered cerebral autoregulation. Nevertheless, cerebral hemodynamics and oxygenation, as well as the effects of the different therapeutics on it have been poorly studied in critically-ill patients. In addition, it has been suggested that impaired cerebral blood flow and impaired cerebral microcirculation may be involved in the pathophysiology of septic encephalopathy in patients with sepsis and/or septic shock. In this study, we aimed to characterize and investigate the effects of different therapeutics on cerebral hemodynamics and oxygenation in critically-ill patients.

Interventions

PROCEDUREmechanical ventilation

mechanical vantilation will be performed

DRUGSedation

sedation wil be performed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

: * Patients under mechanical ventilation and sedated within the first 72h of ventilation onset * Indication to one of the studied therapeutics left at the discretion of the attending physician

Exclusion criteria

* Age \< 18 years * Pregnancy * Inability to obtain a Doppler signal * Medical history or clinical evidence of neurological disease * Known severe carotid stenosis (\>70%) * Significant cardiac arrhythmias * Care-limitation decision.

Design outcomes

Primary

Measure	Time frame	Description
Cerebral blood flow	Within the first 72 hours of ventilation onset, before and after therapeutics	Use of transcranial Doppler

Secondary

Measure	Time frame	Description
Cerebral autoregulation	Within the first 72 hours of ventilation onset, before and after therapeutics	Use of transcranial Doppler

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 27, 2026