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Patient Time and In-hospital Delay of Surgery Association With Complicated Appendicitis

In-hospital Delay of Surgery Increases the Rate of Complicated Appendicitis in Patients Presenting With Short Duration of Symptoms: a Retrospective Cohort Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04689906
Enrollment
3137
Registered
2020-12-30
Start date
2006-12-01
Completion date
2017-08-01
Last updated
2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Appendicitis

Keywords

Appendicitis, Ruptured Appendicitis, Appendectomy, Timing of Surgery

Brief summary

This is a retrospective observational study with its main aim of evaluating possible factors associated with complicated appendicitis. Current literature supports time from symptom onset until registration as the main and maybe only determinant of the outcome if patients are operated on within 24 hours. We wish to evaluate whether this is true in all patients, or there are subgroups in which time from registration to operation is associated with complicated appendicitis.

Detailed description

The data to be analyzed is that of patients operated on acutely for suspected appendicitis within 10 years in one medical center. Patients undergoing interval or incidental appendectomies will not be included. The endpoint to be evaluated is complicated appendicitis (gangrenous, abscess, perforated). The independent variables will include mainly sex, age, patient time (time from symptom onset to registration), hospital time (time from registration to operation), and missed diagnosis.

Interventions

OTHERsurgery

This is a retrospective study that includes patients operated for suspicion of acute appendicitis

Sponsors

Hillel Yaffe Medical Center
CollaboratorOTHER_GOV
Rambam Health Care Campus
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* male and female patients of all ages who underwent appendectomy of acute appendicitis in a single medical center between December 1, 2006, and December 31, 2016

Exclusion criteria

* interval appendectomy, * incidental appendectomy, * appendectomy after failed antibiotic treatment for either acute appendicitis or peri-appendicular abscess * patients with a non-inflamed appendix * those in whom symptom onset before hospitalization was not noted.

Design outcomes

Primary

MeasureTime frameDescription
proportion of complicated appendicitisfinding during surgery/pathologycomplicated appendicitis defined as either gangrenous appendicitis, perforation with abscess, perforation with local peritonitis, perforation with diffuse peritonitis

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 19, 2026