COVID-19, Endothelial Function
Conditions
Keywords
COVID-19
Brief summary
The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality in ICU COVID-19 patients.
Detailed description
After giving consent to participate in the study, the subjects included in the study will undergo a 15-minute measurement of tissue oxygen saturation (StO2) measured non-invasively on the forearm by means of near-infrared spectroscopy (NIRS). Once a baseline stable StO2 value is obtained, a provocative test, consisting of a transient vascular occlusion, will be performed. The test will allow the obtention of a local metabolic rate, and a StO2 recovery rate after the ischemic stimulus. This StO2 recovery rate will be considered as a reflection of the endothelial health of the patient. Patients will be studied as soon as possible after admission to the ICU, and followed-up until ICU discharge or death.
Interventions
DEVICEVascular occlusion test
The ischemic challenge will consist in a standardized Vascular Occlusion Test (VOT), as previously described in the literature. Briefly, a blood pressure cuff will be placed proximal to the forearm, and rapidly inflated at 40 mmHg above systolic pressure, and kept inflated during three minutes. Then the cuff will be rapidly deflated. The resulting deoxygenation (DeO2) and reoxygenation (ReO2) slopes will be reported as change in O2 saturation over time.
Sponsors
Institut de Ciències Fotòniques (ICFO)
Centre de Recerca Matemàtica
Institute of Physics University of Campinas
Corporacion Parc Tauli
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Recent diagnosis of SARS-CoV2 infection * Arterial hypoxemia and bilateral alveolar infiltrates, not explained by cardiac dysfunction or fluid overload.
Exclusion criteria
* Severe peripheral vasculopathy * Raynaud's syndrome * Skin lesions or trauma in upper limbs interfering the placement of NIRS probe and/or the occlusion tourniquet * Deep venous thrombosis in the upper limbs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 28-day mortality | 28 days | Mortality at 28 days of patients admitted to the ICU as results of respiratory failure secondary to COVID-19 |
Countries
Brazil, Mexico, Spain, United States
Contacts
Primary ContactJaume Mesquida, MD, PhD
Outcome results
None listed