Thrombolysis With Intra-arterial Urokinase

Thrombolysis With Intra-arterial Urokinase for Acute Superior Mesenteric Artery Occlusion: Outcome Analysis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04688879

Enrollment

Registered

2020-12-30

Start date

2020-03-01

Completion date

2020-09-01

Last updated

2020-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Arterial Occlusion Mesenteric Artery Superior

Keywords

intra-arterial urokinase

Brief summary

Patients with acute superior mesenteric artery (SMA) occlusion were included in this study. The clinical presentation and effect of the recanalization of the SMA was analyzed on follow-up angiography.

Detailed description

Thirteen patients with acute SMA occlusion who underwent intra-arterial urokinase thrombolysis between 2008 and 2020 were retrospectively evaluated. Clinically, the abdominal pain and the effect of the SMA on angiography will be compared in response and non-response groups.

Interventions

PROCEDUREintra-arterial urokinase thrombolysis

Under local anaesthesia, the right femoral artery was punctured in accordance with the Seldinger technique, and a 6-Fr sheath, 10 cm in length, was implanted. Selective catheterization of the SMA was performed with 4-Fr catheter. The SMA angiography was performed to identify the filling defect. Thrombolysis was performed using a 5-Fr multiple-sideport infusion catheter (100cm with sideport of 7cm, 14 ports or 100cm with sideport of 15cm, 30 ports, Cook, Bloomington, IN, U.S.A). The tip of the microcatheter was embedded in the thromboembolism, which was fragmented at the time of thrombolysis. Thrombolysis was performed locally in the SMA with a bolus of urokinase

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of SMA occlusion

Exclusion criteria

* shock in the triage screening * peritonitis * 3\. intramural gas, mesenteric or portal venous gas on contrast-enhanced abdominal CT

Design outcomes

Primary

Measure	Time frame	Description
Thrombolysis with intra-arterial urokinase for acute superior mesenteric artery occlusion: Outcome analysis	Daily series follow-up angiography in the next 72 hours after thrombolysis with intra-arterial urokinase.	Degree of patency and appearance of the SMA will be analyzed in the follow-up angiography.

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026